4-(3-nitrophenylsulfanyl)imidazole-1-sulfonic acid dimethylamide

Base Information

• Chemical Name: 4-(3-nitrophenylsulfanyl)imidazole-1-sulfonic acid dimethylamide
• CAS No.: 725233-26-1
• Molecular Formula: C₁₁H₁₂N₄O₄S₂
• Molecular Weight: 328.373
• Mol file: 725233-26-1.mol

Synonyms:4-(3-nitrophenylsulfanyl)imidazole-1-sulfonic acid dimethylamide

Chemical Property of 4-(3-nitrophenylsulfanyl)imidazole-1-sulfonic acid dimethylamide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 4-(3-nitrophenylsulfanyl)imidazole-1-sulfonic acid dimethylamide

There total 1 articles about 4-(3-nitrophenylsulfanyl)imidazole-1-sulfonic acid dimethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

bis(3-nitrophenyl) disulfide (537-91-7) + 4-iodo-N,N-dimethyl-1H-imidazole-1-sulfonamide (135773-25-0) → 4-(3-nitrophenylsulfanyl)imidazole-1-sulfonic acid dimethylamide (725233-26-1)

Guidance literature:

4-iodo-N,N-dimethyl-1H-imidazole-1-sulfonamide; With ethylmagnesium bromide; In tetrahydrofuran; diethyl ether; at -78 ℃; for 0.25h;

bis(3-nitrophenyl) disulfide; In tetrahydrofuran; diethyl ether; at 0 ℃; for 0.75h;

DOI:10.1021/jm030551a

Reference yield:

4-(3-nitrophenylsulfanyl)imidazole-1-sulfonic acid dimethylamide (725233-26-1) → 4-(3-aminophenylsulfanyl)imidazole-1-sulfonic acid dimethylamide (725233-27-2)

Guidance literature:

With iron; ammonium chloride; In ethanol; for 16h; Heating;

DOI:10.1021/jm030551a

Reference yield:

4-(3-nitrophenylsulfanyl)imidazole-1-sulfonic acid dimethylamide (725233-26-1) → ethanesulfonic acid [3-(1H-imidazol-4-ylsulfanyl)-phenyl]-amide

Guidance literature:

Multi-step reaction with 3 steps

1: 0.95 g / aq. NH₄Cl; Fe / ethanol / 16 h / Heating

2: 81 percent / pyridine / CH₂Cl₂ / 20 °C

3: 41 percent / aq. HCl / tetrahydrofuran / 2 h / Heating

With pyridine; hydrogenchloride; iron; ammonium chloride; In tetrahydrofuran; ethanol; dichloromethane;

DOI:10.1021/jm030551a

upstream raw materials:

bis(3-nitrophenyl) disulfide

4-iodo-N,N-dimethyl-1H-imidazole-1-sulfonamide

Downstream raw materials:

4-(3-aminophenylsulfanyl)imidazole-1-sulfonic acid dimethylamide

4-(3-ethanesulfonylaminophenylsulfanyl)imidazole-1-sulfonic acid dimethylamide