(3R,1'R,2'R)-N-methyl-N-(2'-phenyl-2'-hydroxy-1'-methylethyl)-3-methylpentanamide

Base Information

Chemical Name:(3R,1'R,2'R)-N-methyl-N-(2'-phenyl-2'-hydroxy-1'-methylethyl)-3-methylpentanamide
CAS No.:1061728-08-2
Molecular Formula:C₁₆H₂₅NO₂
Molecular Weight:263.38
Hs Code.:

Synonyms:(3R,1'R,2'R)-N-methyl-N-(2'-phenyl-2'-hydroxy-1'-methylethyl)-3-methylpentanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3R,1'R,2'R)-N-methyl-N-(2'-phenyl-2'-hydroxy-1'-methylethyl)-3-methylpentanamide

Chemical Property:

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Technology Process of (3R,1'R,2'R)-N-methyl-N-(2'-phenyl-2'-hydroxy-1'-methylethyl)-3-methylpentanamide

There total 2 articles about (3R,1'R,2'R)-N-methyl-N-(2'-phenyl-2'-hydroxy-1'-methylethyl)-3-methylpentanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 16958-25-1
(R)-3-methylpentanoic acid

: 321-97-1,7009-81-6,90-83-5,6912-63-6
(1R,2R)-pseudoephedrine

: 1061728-08-2
(3R,1'R,2'R)-N-methyl-N-(2'-phenyl-2'-hydroxy-1'-methylethyl)-3-methylpentanamide

Guidance literature:: (R)-3-methylpentanoic acid; With pivaloyl chloride; triethylamine; In dichloromethane; at -5 ℃; for 1h; Inert atmosphere;

(1R,2R)-pseudoephedrine; With triethylamine; In dichloromethane; at 5 ℃; Inert atmosphere;
DOI:10.1021/jm4007565

Reference yield:

: 1061728-06-0
(E)-(-)-(1'R,2'R)-N-methyl-N-(2'-phenyl-2'-hydroxy-1'-methylethyl)but-2-enamide

: 925-90-6
ethylmagnesium bromide

: 1061728-08-2
(3R,1'R,2'R)-N-methyl-N-(2'-phenyl-2'-hydroxy-1'-methylethyl)-3-methylpentanamide

: (S)-3-methylpentanoic acid ((1'R,2'R)-2'-hydroxy-1'-methyl-2'-phenylethyl)(methyl)amide

Guidance literature:: With copper(I) bromide dimethylsulfide complex; In diethyl ether; dichloromethane; at -30 ℃; for 6h; Further Variations:; Solvents; Product distribution;
DOI:10.1016/j.tetasy.2008.06.017

Reference yield: 96.0%

: 1061728-08-2
(3R,1'R,2'R)-N-methyl-N-(2'-phenyl-2'-hydroxy-1'-methylethyl)-3-methylpentanamide

: 107-08-4
1-iodo-propane

: 1449396-56-8
C₁₉H₃₁NO₂

Guidance literature:: (3R,1'R,2'R)-N-methyl-N-(2'-phenyl-2'-hydroxy-1'-methylethyl)-3-methylpentanamide; With n-butyllithium; diisopropylamine; lithium chloride; In tetrahydrofuran; cyclohexane; at -20 - -10 ℃; for 0.5h; Inert atmosphere;

1-iodo-propane; In tetrahydrofuran; cyclohexane; at -10 - 20 ℃;
DOI:10.1021/jm4007565