2,4,5-trimethoxymethamphetamine

Base Information

• Chemical Name: 2,4,5-trimethoxymethamphetamine
• CAS No.: 93675-32-2
• Molecular Formula: C₁₃H₂₁NO₃
• Molecular Weight: 239.315
• Mol file: 93675-32-2.mol

Synonyms:2,4,5-trimethoxymethamphetamine

Chemical Property of 2,4,5-trimethoxymethamphetamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,4,5-trimethoxymethamphetamine

There total 3 articles about 2,4,5-trimethoxymethamphetamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2,4,5-Trimethoxyphenylacetone (2020-90-8) + methylamine (74-89-5) → 2,4,5-trimethoxymethamphetamine (93675-32-2)

Guidance literature:

2,4,5-Trimethoxyphenylacetone; methylamine; In tetrahydrofuran; dichloromethane; at -5 - 20 ℃; for 1h;

With sodium tris(acetoxy)borohydride; acetic acid; at 20 ℃; for 3h;

DOI:10.1021/tx2001459

Reference yield:

asaraldehyde (4460-86-0,14374-62-0) → 2,4,5-trimethoxymethamphetamine (93675-32-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: ammonium acetate / 0.75 h / Reflux

2.1: hydrogenchloride; iron(III) chloride; water; iron / toluene / 6 h / Reflux

3.1: tetrahydrofuran; dichloromethane / 1 h / -5 - 20 °C

3.2: 3 h / 20 °C

With hydrogenchloride; iron(III) chloride; ammonium acetate; water; iron; In tetrahydrofuran; dichloromethane; toluene;

DOI:10.1021/tx2001459

Reference yield:

2,4,5-trimethoxy-β-methyl-β-nitrostyrene (134040-35-0,17231-84-4) → 2,4,5-trimethoxymethamphetamine (93675-32-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogenchloride; iron(III) chloride; water; iron / toluene / 6 h / Reflux

2.1: tetrahydrofuran; dichloromethane / 1 h / -5 - 20 °C

2.2: 3 h / 20 °C

With hydrogenchloride; iron(III) chloride; water; iron; In tetrahydrofuran; dichloromethane; toluene;

DOI:10.1021/tx2001459

upstream raw materials:

asaraldehyde

2,4,5-trimethoxy-β-methyl-β-nitrostyrene

2,4,5-Trimethoxyphenylacetone

methylamine

Downstream raw materials:

C₁₀H₁₃NO₃

(+/-)-2,4,5-trihydroxymethamphetamine hydrobromide