tert-Butoxycarbonylamino-acetic acid 4-{(1S,2R,3R)-1-chloro-3-[(E)-(3S,10R,16S)-10-(3-chloro-4-methoxy-benzyl)-3-isobutyl-6,6-dimethyl-2,5,9,12-tetraoxo-1,4-dioxa-8,11-diaza-cyclohexadec-13-en-16-yl]-2-hydroxy-butyl}-benzyl ester

Base Information

Chemical Name:tert-Butoxycarbonylamino-acetic acid 4-{(1S,2R,3R)-1-chloro-3-[(E)-(3S,10R,16S)-10-(3-chloro-4-methoxy-benzyl)-3-isobutyl-6,6-dimethyl-2,5,9,12-tetraoxo-1,4-dioxa-8,11-diaza-cyclohexadec-13-en-16-yl]-2-hydroxy-butyl}-benzyl ester
CAS No.:204397-74-0
Molecular Formula:C₄₄H₅₉Cl₂N₃O₁₂
Molecular Weight:892.871
Hs Code.:

tert-Butoxycarbonylamino-acetic acid 4-{(1S,2R,3R)-1-chloro-3-[(E)-(3S,10R,16S)-10-(3-chloro-4-methoxy-benzyl)-3-isobutyl-6,6-dimethyl-2,5,9,12-tetraoxo-1,4-dioxa-8,11-diaza-cyclohexadec-13-en-16-yl]-2-hydroxy-butyl}-benzyl ester

Synonyms:tert-Butoxycarbonylamino-acetic acid 4-{(1S,2R,3R)-1-chloro-3-[(E)-(3S,10R,16S)-10-(3-chloro-4-methoxy-benzyl)-3-isobutyl-6,6-dimethyl-2,5,9,12-tetraoxo-1,4-dioxa-8,11-diaza-cyclohexadec-13-en-16-yl]-2-hydroxy-butyl}-benzyl ester

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Chemical Property of tert-Butoxycarbonylamino-acetic acid 4-{(1S,2R,3R)-1-chloro-3-[(E)-(3S,10R,16S)-10-(3-chloro-4-methoxy-benzyl)-3-isobutyl-6,6-dimethyl-2,5,9,12-tetraoxo-1,4-dioxa-8,11-diaza-cyclohexadec-13-en-16-yl]-2-hydroxy-butyl}-benzyl ester

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Technology Process of tert-Butoxycarbonylamino-acetic acid 4-{(1S,2R,3R)-1-chloro-3-[(E)-(3S,10R,16S)-10-(3-chloro-4-methoxy-benzyl)-3-isobutyl-6,6-dimethyl-2,5,9,12-tetraoxo-1,4-dioxa-8,11-diaza-cyclohexadec-13-en-16-yl]-2-hydroxy-butyl}-benzyl ester

There total 10 articles about tert-Butoxycarbonylamino-acetic acid 4-{(1S,2R,3R)-1-chloro-3-[(E)-(3S,10R,16S)-10-(3-chloro-4-methoxy-benzyl)-3-isobutyl-6,6-dimethyl-2,5,9,12-tetraoxo-1,4-dioxa-8,11-diaza-cyclohexadec-13-en-16-yl]-2-hydroxy-butyl}-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 204397-72-8
tert-Butoxycarbonylamino-acetic acid 4-((2R,3R)-3-{(S)-1-[(E)-(3S,10R,16S)-10-(3-chloro-4-methoxy-benzyl)-3-isobutyl-6,6-dimethyl-2,5,9,12-tetraoxo-1,4-dioxa-8,11-diaza-cyclohexadec-13-en-16-yl]-ethyl}-oxiranyl)-benzyl ester

: 204397-74-0
tert-Butoxycarbonylamino-acetic acid 4-{(1S,2R,3R)-1-chloro-3-[(E)-(3S,10R,16S)-10-(3-chloro-4-methoxy-benzyl)-3-isobutyl-6,6-dimethyl-2,5,9,12-tetraoxo-1,4-dioxa-8,11-diaza-cyclohexadec-13-en-16-yl]-2-hydroxy-butyl}-benzyl ester

Guidance literature:: With chloro-trimethyl-silane; In chloroform; at -60 - 20 ℃; for 5h;

Reference yield: 35.0%

: 204397-72-8
tert-Butoxycarbonylamino-acetic acid 4-((2R,3R)-3-{(S)-1-[(E)-(3S,10R,16S)-10-(3-chloro-4-methoxy-benzyl)-3-isobutyl-6,6-dimethyl-2,5,9,12-tetraoxo-1,4-dioxa-8,11-diaza-cyclohexadec-13-en-16-yl]-ethyl}-oxiranyl)-benzyl ester

: tert-Butoxycarbonylamino-acetic acid 4-{(1R,2R,3R)-1-chloro-3-[(E)-(3S,10R,16S)-10-(3-chloro-4-methoxy-benzyl)-3-isobutyl-6,6-dimethyl-2,5,9,12-tetraoxo-1,4-dioxa-8,11-diaza-cyclohexadec-13-en-16-yl]-2-hydroxy-butyl}-benzyl ester

: 204397-74-0
tert-Butoxycarbonylamino-acetic acid 4-{(1S,2R,3R)-1-chloro-3-[(E)-(3S,10R,16S)-10-(3-chloro-4-methoxy-benzyl)-3-isobutyl-6,6-dimethyl-2,5,9,12-tetraoxo-1,4-dioxa-8,11-diaza-cyclohexadec-13-en-16-yl]-2-hydroxy-butyl}-benzyl ester

Guidance literature:: With chloro-trimethyl-silane; In chloroform; at -60 - -40 ℃; for 5h;
DOI:10.1021/jm0203884

Reference yield:

: 4530-20-5
BOC-glycine

: 204397-74-0
tert-Butoxycarbonylamino-acetic acid 4-{(1S,2R,3R)-1-chloro-3-[(E)-(3S,10R,16S)-10-(3-chloro-4-methoxy-benzyl)-3-isobutyl-6,6-dimethyl-2,5,9,12-tetraoxo-1,4-dioxa-8,11-diaza-cyclohexadec-13-en-16-yl]-2-hydroxy-butyl}-benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 72 percent / 4-(dimethylamino)pyridine; 1,3-dicyclohexylcarbodiimide / CH₂Cl₂ / 0.92 h / 0 - 20 °C

2: 35 percent / chlorotrimethylsilane / CHCl₃ / 5 h / -60 - -40 °C

With dmap; chloro-trimethyl-silane; dicyclohexyl-carbodiimide; In dichloromethane; chloroform;
DOI:10.1021/jm0203884