(2R,5S,E)-1-((tert-butyldimethylsilyl)oxy)-5-((4-methoxybenzyl)oxy)-2-methyl-9-((tetrahydro-2H-pyran-2-yl)oxy)non-7-en-4-one

Base Information

Chemical Name:(2R,5S,E)-1-((tert-butyldimethylsilyl)oxy)-5-((4-methoxybenzyl)oxy)-2-methyl-9-((tetrahydro-2H-pyran-2-yl)oxy)non-7-en-4-one
CAS No.:1313511-85-1
Molecular Formula:C₂₉H₄₈O₆Si
Molecular Weight:520.782
Hs Code.:

Synonyms:(2R,5S,E)-1-((tert-butyldimethylsilyl)oxy)-5-((4-methoxybenzyl)oxy)-2-methyl-9-((tetrahydro-2H-pyran-2-yl)oxy)non-7-en-4-one

Suppliers and Price of (2R,5S,E)-1-((tert-butyldimethylsilyl)oxy)-5-((4-methoxybenzyl)oxy)-2-methyl-9-((tetrahydro-2H-pyran-2-yl)oxy)non-7-en-4-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2R,5S,E)-1-((tert-butyldimethylsilyl)oxy)-5-((4-methoxybenzyl)oxy)-2-methyl-9-((tetrahydro-2H-pyran-2-yl)oxy)non-7-en-4-one

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R,5S,E)-1-((tert-butyldimethylsilyl)oxy)-5-((4-methoxybenzyl)oxy)-2-methyl-9-((tetrahydro-2H-pyran-2-yl)oxy)non-7-en-4-one

There total 11 articles about (2R,5S,E)-1-((tert-butyldimethylsilyl)oxy)-5-((4-methoxybenzyl)oxy)-2-methyl-9-((tetrahydro-2H-pyran-2-yl)oxy)non-7-en-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1313511-73-7
(2S,E)-N-methoxy-2-((4-methoxybenzyl)oxy)-N-methyl-6-((tetrahydro-2H-pyran-2-yl)oxy)hex-4-enamide

: 168335-78-2
(2S)-(+)-(tert-butyl-dimethyl)-(3-iodo-2-methyl-propoxy)-silane

: 1313511-85-1
(2R,5S,E)-1-((tert-butyldimethylsilyl)oxy)-5-((4-methoxybenzyl)oxy)-2-methyl-9-((tetrahydro-2H-pyran-2-yl)oxy)non-7-en-4-one

Guidance literature:: (2S)-(+)-(tert-butyl-dimethyl)-(3-iodo-2-methyl-propoxy)-silane; With tert.-butyl lithium; In diethyl ether; pentane; at -78 ℃; for 0.25h;

(2S,E)-N-methoxy-2-((4-methoxybenzyl)oxy)-N-methyl-6-((tetrahydro-2H-pyran-2-yl)oxy)hex-4-enamide; In tetrahydrofuran; diethyl ether; pentane; at -78 ℃;
DOI:10.1039/c0ob01253j

Reference yield:

: C₁₇H₂₃NO₄

: 1313511-85-1
(2R,5S,E)-1-((tert-butyldimethylsilyl)oxy)-5-((4-methoxybenzyl)oxy)-2-methyl-9-((tetrahydro-2H-pyran-2-yl)oxy)non-7-en-4-one

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium tetrahydroborate / ethanol; water; dimethyl sulfoxide / 0.5 h / 20 °C

2.1: acetic acid; zinc / ethanol / 2 h / 20 °C

3.1: 1H-imidazole / N,N-dimethyl-formamide / 6 h / 20 °C

4.1: camphor-10-sulfonic acid / dichloromethane / 20 °C

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C

6.1: sulfur trioxide pyridine complex; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C

7.1: sodium dihydrogenphosphate; sodium chlorite / 2-methyl-but-2-ene; water; tert-butyl alcohol / 0.5 h / 0 °C

8.1: 1,1'-carbonyldiimidazole / dichloromethane / 0 °C

9.1: tert.-butyl lithium / diethyl ether; pentane / 0.25 h / -78 °C

9.2: -78 °C

With 1H-imidazole; sodium chlorite; sodium tetrahydroborate; sodium dihydrogenphosphate; camphor-10-sulfonic acid; tetrabutyl ammonium fluoride; tert.-butyl lithium; sulfur trioxide pyridine complex; acetic acid; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole; zinc; In tetrahydrofuran; 2-methyl-but-2-ene; diethyl ether; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; tert-butyl alcohol; pentane; 6.1: Parikh-Doering oxidation;
DOI:10.1039/c0ob01253j

Reference yield:

: C₁₇H₂₅NO₄

: 1313511-85-1
(2R,5S,E)-1-((tert-butyldimethylsilyl)oxy)-5-((4-methoxybenzyl)oxy)-2-methyl-9-((tetrahydro-2H-pyran-2-yl)oxy)non-7-en-4-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: acetic acid; zinc / ethanol / 2 h / 20 °C

2.1: 1H-imidazole / N,N-dimethyl-formamide / 6 h / 20 °C

3.1: camphor-10-sulfonic acid / dichloromethane / 20 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C

5.1: sulfur trioxide pyridine complex; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C

6.1: sodium dihydrogenphosphate; sodium chlorite / 2-methyl-but-2-ene; water; tert-butyl alcohol / 0.5 h / 0 °C

7.1: 1,1'-carbonyldiimidazole / dichloromethane / 0 °C

8.1: tert.-butyl lithium / diethyl ether; pentane / 0.25 h / -78 °C

8.2: -78 °C

With 1H-imidazole; sodium chlorite; sodium dihydrogenphosphate; camphor-10-sulfonic acid; tetrabutyl ammonium fluoride; tert.-butyl lithium; sulfur trioxide pyridine complex; acetic acid; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole; zinc; In tetrahydrofuran; 2-methyl-but-2-ene; diethyl ether; ethanol; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol; pentane; 5.1: Parikh-Doering oxidation;
DOI:10.1039/c0ob01253j