3-(cyclopropylmethyl)-N-[1-(2,4-difluorophenyl)-4-piperidinyl]-8-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyridine-7-methanamine

Base Information

Chemical Name:3-(cyclopropylmethyl)-N-[1-(2,4-difluorophenyl)-4-piperidinyl]-8-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyridine-7-methanamine
CAS No.:1374582-87-2
Molecular Formula:C₂₃H₂₄F₅N₅
Molecular Weight:465.469
Hs Code.:

Synonyms:3-(cyclopropylmethyl)-N-[1-(2,4-difluorophenyl)-4-piperidinyl]-8-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyridine-7-methanamine

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Chemical Property of 3-(cyclopropylmethyl)-N-[1-(2,4-difluorophenyl)-4-piperidinyl]-8-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyridine-7-methanamine

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Technology Process of 3-(cyclopropylmethyl)-N-[1-(2,4-difluorophenyl)-4-piperidinyl]-8-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyridine-7-methanamine

There total 9 articles about 3-(cyclopropylmethyl)-N-[1-(2,4-difluorophenyl)-4-piperidinyl]-8-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyridine-7-methanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.3%

: 1016777-81-3
1-(2,4-difluorophenyl)piperidin-4-amine

: 7-carboxaldehyde-3-cyclopropylmethyl-8-trifluoromethyl[1,2,4]triazolo[4,3-a]pyridine

: 1374582-87-2
3-(cyclopropylmethyl)-N-[1-(2,4-difluorophenyl)-4-piperidinyl]-8-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyridine-7-methanamine

Guidance literature:: 1-(2,4-difluorophenyl)piperidin-4-amine; 7-carboxaldehyde-3-cyclopropylmethyl-8-trifluoromethyl[1,2,4]triazolo[4,3-a]pyridine; In 1,2-dichloro-ethane; at 20 ℃; for 18h;

With sodium tris(acetoxy)borohydride; acetic acid; In 1,2-dichloro-ethane; at 20 ℃; for 20h;

Reference yield:

: 26452-80-2
2,4-dichloropyridine

: 1374582-87-2
3-(cyclopropylmethyl)-N-[1-(2,4-difluorophenyl)-4-piperidinyl]-8-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyridine-7-methanamine

Guidance literature:: Multi-step reaction with 9 steps

1.1: N-ethyl-N,N-diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 0.75 h / -78 °C / Inert atmosphere

1.2: 1 h / -78 °C

2.1: copper(l) iodide / N,N-dimethyl-formamide / 5 h / 100 °C / Sealed tube

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 - 20 °C

4.1: hydrazine hydrate / 1,4-dioxane / 0.5 h / 160 °C / Microwave irradiation

5.1: triethylamine / N,N-dimethyl-formamide / 0.33 h / 0 °C

6.1: trichlorophosphate / acetonitrile / 0.17 h / 150 °C / Microwave irradiation

7.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.22 h / 150 °C / Microwave irradiation

8.1: osmium(VIII) oxide; sodium periodate / 1,4-dioxane; water; tert-butyl alcohol / 2 h / 20 °C

9.1: 1,2-dichloro-ethane / 18 h / 20 °C

9.2: 20 h / 20 °C

With sodium periodate; osmium(VIII) oxide; n-butyllithium; sodium hydride; sodium hydrogencarbonate; hydrazine hydrate; triethylamine; N-ethyl-N,N-diisopropylamine; trichlorophosphate; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; hexane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile; mineral oil; tert-butyl alcohol;

Reference yield:

: 1186194-98-8
2,4-dichloro-3-(trifluoromethyl)pyridine

: 1374582-87-2
3-(cyclopropylmethyl)-N-[1-(2,4-difluorophenyl)-4-piperidinyl]-8-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyridine-7-methanamine

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 - 20 °C

2.1: hydrazine hydrate / 1,4-dioxane / 0.5 h / 160 °C / Microwave irradiation

3.1: triethylamine / N,N-dimethyl-formamide / 0.33 h / 0 °C

4.1: trichlorophosphate / acetonitrile / 0.17 h / 150 °C / Microwave irradiation

5.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.22 h / 150 °C / Microwave irradiation

6.1: osmium(VIII) oxide; sodium periodate / 1,4-dioxane; water; tert-butyl alcohol / 2 h / 20 °C

7.1: 1,2-dichloro-ethane / 18 h / 20 °C

7.2: 20 h / 20 °C

With sodium periodate; osmium(VIII) oxide; sodium hydride; sodium hydrogencarbonate; hydrazine hydrate; triethylamine; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile; mineral oil; tert-butyl alcohol;