2,2-dimethyl-propionic acid 2-(diphenyl-phosphinoyl)-3-iodo-4-methoxy-phenyl ester

Base Information

Chemical Name:2,2-dimethyl-propionic acid 2-(diphenyl-phosphinoyl)-3-iodo-4-methoxy-phenyl ester
CAS No.:716315-42-3
Molecular Formula:C₂₄H₂₄IO₄P
Molecular Weight:534.33
Hs Code.:

Synonyms:2,2-dimethyl-propionic acid 2-(diphenyl-phosphinoyl)-3-iodo-4-methoxy-phenyl ester

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Chemical Property of 2,2-dimethyl-propionic acid 2-(diphenyl-phosphinoyl)-3-iodo-4-methoxy-phenyl ester

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Technology Process of 2,2-dimethyl-propionic acid 2-(diphenyl-phosphinoyl)-3-iodo-4-methoxy-phenyl ester

There total 5 articles about 2,2-dimethyl-propionic acid 2-(diphenyl-phosphinoyl)-3-iodo-4-methoxy-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 716315-40-1
2,2-dimethyl-propionic acid 2-(diphenyl-phosphinoyl)-4-methoxy-phenyl ester

: 716315-42-3
2,2-dimethyl-propionic acid 2-(diphenyl-phosphinoyl)-3-iodo-4-methoxy-phenyl ester

Guidance literature:: 2,2-dimethyl-propionic acid 2-(diphenyl-phosphinoyl)-4-methoxy-phenyl ester; With lithium diisopropyl amide; In tetrahydrofuran; at -75 ℃; for 2h;

With iodine; In tetrahydrofuran; at 20 ℃; for 1h; Further stages.;
DOI:10.1016/j.tetlet.2004.03.073

Reference yield:

: 34253-15-1
4-methoxy-o-phenyl phenyl(phenyl)phosphinate

: 716315-42-3
2,2-dimethyl-propionic acid 2-(diphenyl-phosphinoyl)-3-iodo-4-methoxy-phenyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 74 percent / LDA / tetrahydrofuran / 6 h / -60 °C

2.1: 99 percent / Et₃N / CH₂Cl₂

3.1: LDA / tetrahydrofuran / 2 h / -75 °C

3.2: 98 percent / I₂ / tetrahydrofuran / 1 h / 20 °C

With triethylamine; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tetlet.2004.03.073

Reference yield:

: 150-76-5
4-methoxy-phenol

: 716315-42-3
2,2-dimethyl-propionic acid 2-(diphenyl-phosphinoyl)-3-iodo-4-methoxy-phenyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: Et₃N / CH₂Cl₂ / 12 h / 20 °C

1.2: 99 percent / H₂O₂

2.1: 74 percent / LDA / tetrahydrofuran / 6 h / -60 °C

3.1: 99 percent / Et₃N / CH₂Cl₂

4.1: LDA / tetrahydrofuran / 2 h / -75 °C

4.2: 98 percent / I₂ / tetrahydrofuran / 1 h / 20 °C

With triethylamine; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tetlet.2004.03.073