(5-methoxy-4-methyl-2-nitrophenyl)acetic acid

Base Information

• Chemical Name: (5-methoxy-4-methyl-2-nitrophenyl)acetic acid
• CAS No.: 56473-72-4
• Molecular Formula: C₁₀H₁₁NO₅
• Molecular Weight: 225.201
• Mol file: 56473-72-4.mol

Synonyms:

Chemical Property of (5-methoxy-4-methyl-2-nitrophenyl)acetic acid

Chemical Property:

• Vapor Pressure: 1.47E-07mmHg at 25°C
• Boiling Point: 412.9°C at 760 mmHg
• Flash Point: 203.5°C
• Density: 1.332g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (5-methoxy-4-methyl-2-nitrophenyl)acetic acid

There total 5 articles about (5-methoxy-4-methyl-2-nitrophenyl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,5-Dimethylphenol (95-87-4) → 2-(5-Methoxy-4-methyl-2-nitrophenyl)essigsaeure (56473-72-4)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium nitrite, conc. H₂SO₄ / acetic acid; H₂O / 0.17 h / 8 - 10 °C

2: 68percent HNO₃ / H₂O / 0.25 h / 45 °C

3: 58 percent / NaOH / H₂O / 2 h / 40 - 45 °C

4: 1) KOtBu, 2) 10percent H₂O₂, 3N NaOH / 1) benzene; 24h, reflux; 24h, r.t.

With sodium hydroxide; sulfuric acid; potassium tert-butylate; dihydrogen peroxide; nitric acid; sodium nitrite; In water; acetic acid;

DOI:10.1002/jlac.198519850711

Reference yield:

4-Nitroso-2,5-xylenol (20294-63-7) → 2-(5-Methoxy-4-methyl-2-nitrophenyl)essigsaeure (56473-72-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 68percent HNO₃ / H₂O / 0.25 h / 45 °C

2: 58 percent / NaOH / H₂O / 2 h / 40 - 45 °C

3: 1) KOtBu, 2) 10percent H₂O₂, 3N NaOH / 1) benzene; 24h, reflux; 24h, r.t.

With sodium hydroxide; potassium tert-butylate; dihydrogen peroxide; nitric acid; In water;

DOI:10.1002/jlac.198519850711

Reference yield:

4-nitro-2,5-xylenol (3139-05-7) → 2-(5-Methoxy-4-methyl-2-nitrophenyl)essigsaeure (56473-72-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 58 percent / NaOH / H₂O / 2 h / 40 - 45 °C

2: 1) KOtBu, 2) 10percent H₂O₂, 3N NaOH / 1) benzene; 24h, reflux; 24h, r.t.

With sodium hydroxide; potassium tert-butylate; dihydrogen peroxide; In water;

DOI:10.1002/jlac.198519850711

upstream raw materials:

1-methoxy-2,5-dimethyl-4-nitrobenzene

oxalic acid diethyl ester

2,5-Dimethylphenol

4-Nitroso-2,5-xylenol

Downstream raw materials:

N-<2-(tert-Butoxycarbonylmethyl)-4-methoxy-5-methylphenyl>succinamsaeure

2-<2-(2,5-Dioxo-1-pyrrolidinyl)-5-methoxy-4-methylphenyl>essigsaeure-tert-butylester

2-<2-(2,5-Dioxo-1-pyrrolidinyl)-5-methoxy-4-methylphenyl>essigsaeure

2-(2-Amino-5-methoxy-4-methylphenyl)essigsaeure-tert-butylester