3-(4-chlorophenyl)-2-(((1-(4-chlorophenyl)-1H-1,2,3-triazol-4-yl)methyl)thio) quinazolin-4(3H)-one

Base Information

Chemical Name:3-(4-chlorophenyl)-2-(((1-(4-chlorophenyl)-1H-1,2,3-triazol-4-yl)methyl)thio) quinazolin-4(3H)-one
CAS No.:1380091-14-4
Molecular Formula:C₂₃H₁₅Cl₂N₅OS
Molecular Weight:480.377
Hs Code.:

Synonyms:3-(4-chlorophenyl)-2-(((1-(4-chlorophenyl)-1H-1,2,3-triazol-4-yl)methyl)thio) quinazolin-4(3H)-one

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Chemical Property of 3-(4-chlorophenyl)-2-(((1-(4-chlorophenyl)-1H-1,2,3-triazol-4-yl)methyl)thio) quinazolin-4(3H)-one

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Technology Process of 3-(4-chlorophenyl)-2-(((1-(4-chlorophenyl)-1H-1,2,3-triazol-4-yl)methyl)thio) quinazolin-4(3H)-one

There total 6 articles about 3-(4-chlorophenyl)-2-(((1-(4-chlorophenyl)-1H-1,2,3-triazol-4-yl)methyl)thio) quinazolin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 3296-05-7
1-azido-4-chlorobenzene

: 883099-89-6
3-(4-chlorophenyl)-2-(prop-2-yn-1-ylthio)quinazolin-4(3H)-one

: 1380091-14-4
3-(4-chlorophenyl)-2-(((1-(4-chlorophenyl)-1H-1,2,3-triazol-4-yl)methyl)thio) quinazolin-4(3H)-one

Guidance literature:: With copper(ll) sulfate pentahydrate; ascorbic acid; In water; N,N-dimethyl-formamide; Reflux;
DOI:10.1016/j.ejmech.2017.12.065

Reference yield: 81.0%

: 3296-05-7
1-azido-4-chlorobenzene

: 106-96-7
propargyl bromide

: 1028-40-6
3-(4-chlorophenyl)-2-thioxo-2,3-dihydro-1H-quinazolin-4-one

: 1380091-14-4
3-(4-chlorophenyl)-2-(((1-(4-chlorophenyl)-1H-1,2,3-triazol-4-yl)methyl)thio) quinazolin-4(3H)-one

Guidance literature:: With sodium 2-(1,2-dihydroxyethyl)-4-hydroxy-5-oxo-2,5-dihydro-furan-3-olate; copper diacetate; potassium carbonate; In ethanol; water; at 80 ℃; for 8h;
DOI:10.1080/00397911.2011.558968

Reference yield:

: 118-92-3,159201-01-1,50816-84-7,80206-34-4,104809-47-4
anthranilic acid

: 1380091-14-4
3-(4-chlorophenyl)-2-(((1-(4-chlorophenyl)-1H-1,2,3-triazol-4-yl)methyl)thio) quinazolin-4(3H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: potassium hydroxide / methanol / Reflux

2: potassium carbonate / N,N-dimethyl-formamide / 3 h / 60 °C

3: copper(ll) sulfate pentahydrate; ascorbic acid / N,N-dimethyl-formamide; water / Reflux

With copper(ll) sulfate pentahydrate; potassium carbonate; potassium hydroxide; ascorbic acid; In methanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2017.12.065