(2S)-2-tert-butoxycarbonylamino-5-{2-[4-(2-fluoro-ethoxy)-phenyl]-ethyl}hexanedioic acid di-tert-butyl ester

Base Information

Chemical Name:(2S)-2-tert-butoxycarbonylamino-5-{2-[4-(2-fluoro-ethoxy)-phenyl]-ethyl}hexanedioic acid di-tert-butyl ester
CAS No.:1408447-04-0
Molecular Formula:C₂₉H₄₆FNO₇
Molecular Weight:539.685
Hs Code.:

Synonyms:(2S)-2-tert-butoxycarbonylamino-5-{2-[4-(2-fluoro-ethoxy)-phenyl]-ethyl}hexanedioic acid di-tert-butyl ester

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Chemical Property of (2S)-2-tert-butoxycarbonylamino-5-{2-[4-(2-fluoro-ethoxy)-phenyl]-ethyl}hexanedioic acid di-tert-butyl ester

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Technology Process of (2S)-2-tert-butoxycarbonylamino-5-{2-[4-(2-fluoro-ethoxy)-phenyl]-ethyl}hexanedioic acid di-tert-butyl ester

There total 8 articles about (2S)-2-tert-butoxycarbonylamino-5-{2-[4-(2-fluoro-ethoxy)-phenyl]-ethyl}hexanedioic acid di-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 762-51-6
1-fluoro-2-iodoethane

: 1408447-37-9
di-tert-butyl (2S)-2-[(tert-butoxycarbonyl)amino]-5-[2-(4-hydroxyphenyl)ethyl]hexanedioate

: 1408447-04-0
(2S)-2-tert-butoxycarbonylamino-5-{2-[4-(2-fluoro-ethoxy)-phenyl]-ethyl}hexanedioic acid di-tert-butyl ester

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 81323-58-2
N-(tert-butyloxycarbonyl)-(S)-homoserine tert-butyl ester

: 1408447-04-0
(2S)-2-tert-butoxycarbonylamino-5-{2-[4-(2-fluoro-ethoxy)-phenyl]-ethyl}hexanedioic acid di-tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-Bromosuccinimide / dichloromethane / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C

2.2: 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C / Inert atmosphere

3.2: 3 h / 60 °C

4.1: hydrogen / palladium 10% on activated carbon / methanol / 16 h / 20 °C

5.1: dmap / 1,4-dioxane / 100 °C / Reflux

6.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

With dmap; N-Bromosuccinimide; hydrogen; sodium hydride; potassium carbonate; palladium 10% on activated carbon; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 163210-89-7
tert-butyl (S)-2-[(tert-butoxycarbonyl)amino]-4-bromobutanoate

: 1408447-04-0
(2S)-2-tert-butoxycarbonylamino-5-{2-[4-(2-fluoro-ethoxy)-phenyl]-ethyl}hexanedioic acid di-tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C

1.2: 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C / Inert atmosphere

2.2: 3 h / 60 °C

3.1: hydrogen / palladium 10% on activated carbon / methanol / 16 h / 20 °C

4.1: dmap / 1,4-dioxane / 100 °C / Reflux

5.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

With dmap; hydrogen; sodium hydride; potassium carbonate; palladium 10% on activated carbon; In 1,4-dioxane; methanol; N,N-dimethyl-formamide; mineral oil;