(2S)-2-amino-5-{2-[4-(2-fluoroethoxy)phenyl]ethyl}hexanedioic acid trifluoroacetate

Base Information

Chemical Name:(2S)-2-amino-5-{2-[4-(2-fluoroethoxy)phenyl]ethyl}hexanedioic acid trifluoroacetate
CAS No.:1408443-57-1
Molecular Formula:C₂HF₃O₂*C₁₆H₂₂FNO₅
Molecular Weight:441.377
Hs Code.:

Synonyms:(2S)-2-amino-5-{2-[4-(2-fluoroethoxy)phenyl]ethyl}hexanedioic acid trifluoroacetate

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Chemical Property of (2S)-2-amino-5-{2-[4-(2-fluoroethoxy)phenyl]ethyl}hexanedioic acid trifluoroacetate

Chemical Property:

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Technology Process of (2S)-2-amino-5-{2-[4-(2-fluoroethoxy)phenyl]ethyl}hexanedioic acid trifluoroacetate

There total 7 articles about (2S)-2-amino-5-{2-[4-(2-fluoroethoxy)phenyl]ethyl}hexanedioic acid trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.0%

: 1408447-04-0
(2S)-2-tert-butoxycarbonylamino-5-{2-[4-(2-fluoro-ethoxy)-phenyl]-ethyl}hexanedioic acid di-tert-butyl ester

: 76-05-1
trifluoroacetic acid

: 1408443-57-1
(2S)-2-amino-5-{2-[4-(2-fluoroethoxy)phenyl]ethyl}hexanedioic acid trifluoroacetate

Guidance literature:: In dichloromethane; at 20 ℃; for 0.5h;

Reference yield:

: 52446-52-3
1-bromo-2-(4-benzyloxyphenyl)ethane

: 1408443-57-1
(2S)-2-amino-5-{2-[4-(2-fluoroethoxy)phenyl]ethyl}hexanedioic acid trifluoroacetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C / Inert atmosphere

1.2: 3 h / 60 °C

2.1: hydrogen / palladium 10% on activated carbon / methanol / 16 h / 20 °C

3.1: dmap / 1,4-dioxane / 100 °C / Reflux

4.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

5.1: dichloromethane / 0.5 h / 20 °C

With dmap; hydrogen; sodium hydride; potassium carbonate; palladium 10% on activated carbon; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 61439-59-6
2-(4-benzyloxyphenyl)ethanol

: 1408443-57-1
(2S)-2-amino-5-{2-[4-(2-fluoroethoxy)phenyl]ethyl}hexanedioic acid trifluoroacetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 2 h / 0 - 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C / Inert atmosphere

2.2: 3 h / 60 °C

3.1: hydrogen / palladium 10% on activated carbon / methanol / 16 h / 20 °C

4.1: dmap / 1,4-dioxane / 100 °C / Reflux

5.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

6.1: dichloromethane / 0.5 h / 20 °C

With dmap; carbon tetrabromide; hydrogen; sodium hydride; potassium carbonate; triphenylphosphine; palladium 10% on activated carbon; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;