1-(2-((4-methoxyphenyl)ethynyl)-3,4-dihydronaphthalen-1-yl)-but-3-en-2-ol

Base Information

Chemical Name:1-(2-((4-methoxyphenyl)ethynyl)-3,4-dihydronaphthalen-1-yl)-but-3-en-2-ol
CAS No.:1603163-82-1
Molecular Formula:C₂₃H₂₂O₂
Molecular Weight:330.426
Hs Code.:

Synonyms:1-(2-((4-methoxyphenyl)ethynyl)-3,4-dihydronaphthalen-1-yl)-but-3-en-2-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(2-((4-methoxyphenyl)ethynyl)-3,4-dihydronaphthalen-1-yl)-but-3-en-2-ol

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Technology Process of 1-(2-((4-methoxyphenyl)ethynyl)-3,4-dihydronaphthalen-1-yl)-but-3-en-2-ol

There total 7 articles about 1-(2-((4-methoxyphenyl)ethynyl)-3,4-dihydronaphthalen-1-yl)-but-3-en-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1603163-98-9
2-(2-((4-methoxyphenyl)ethynyl)-3,4-dihydronaphthalen-1-yl)-acetaldehyde

: 1826-67-1
vinyl magnesium bromide

: 1603163-82-1
1-(2-((4-methoxyphenyl)ethynyl)-3,4-dihydronaphthalen-1-yl)-but-3-en-2-ol

Guidance literature:: In tetrahydrofuran; at 0 ℃; for 0.5h;
DOI:10.1021/jo500561z

Reference yield:

: C₂₀H₂₆BBr

: 1603163-82-1
1-(2-((4-methoxyphenyl)ethynyl)-3,4-dihydronaphthalen-1-yl)-but-3-en-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: water; sodium perborate tetrahydrate / tetrahydrofuran / 1.17 h / Reflux

2.1: palladium diacetate; triphenylphosphine; triethylamine / tetrahydrofuran / 0.17 h / 20 °C

2.2: 24 h / 90 °C

3.1: Dess-Martin periodane; pyridine / dichloromethane / 1 h / 0 - 20 °C

4.1: tetrahydrofuran / 0.5 h / 0 °C

With pyridine; sodium perborate tetrahydrate; water; palladium diacetate; Dess-Martin periodane; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; 2.1: |Sonogashira Cross-Coupling / 2.2: |Sonogashira Cross-Coupling / 4.1: |Grignard Reaction;
DOI:10.1021/jo500561z

Reference yield:

: 1603164-07-3
2-(2-((4-Methoxyphenyl)ethynyl)-3,4-dihydronaphthalen-1-yl)-ethanol

: 1603163-82-1
1-(2-((4-methoxyphenyl)ethynyl)-3,4-dihydronaphthalen-1-yl)-but-3-en-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1: Dess-Martin periodane; pyridine / dichloromethane / 1 h / 0 - 20 °C

2: tetrahydrofuran / 0.5 h / 0 °C

With pyridine; Dess-Martin periodane; In tetrahydrofuran; dichloromethane; 2: |Grignard Reaction;
DOI:10.1021/jo500561z