9-(2-benzyloxy-ethyl)-2,3,4,9-tetrahydro-1H-carbazole-4-carboxylic acid benzyl-methyl-amide

Base Information

Chemical Name:9-(2-benzyloxy-ethyl)-2,3,4,9-tetrahydro-1H-carbazole-4-carboxylic acid benzyl-methyl-amide
CAS No.:1246453-83-7
Molecular Formula:C₃₀H₃₂N₂O₂
Molecular Weight:452.596
Hs Code.:

Synonyms:9-(2-benzyloxy-ethyl)-2,3,4,9-tetrahydro-1H-carbazole-4-carboxylic acid benzyl-methyl-amide

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Chemical Property of 9-(2-benzyloxy-ethyl)-2,3,4,9-tetrahydro-1H-carbazole-4-carboxylic acid benzyl-methyl-amide

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Technology Process of 9-(2-benzyloxy-ethyl)-2,3,4,9-tetrahydro-1H-carbazole-4-carboxylic acid benzyl-methyl-amide

There total 6 articles about 9-(2-benzyloxy-ethyl)-2,3,4,9-tetrahydro-1H-carbazole-4-carboxylic acid benzyl-methyl-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1246453-82-6
9-(2-benzyloxy-ethyl)-2,3,4,9-tetrahydro-1H-carbazole-4-carboxylic acid

: 103-67-3
benzyl-methyl-amine

: 1246453-83-7
9-(2-benzyloxy-ethyl)-2,3,4,9-tetrahydro-1H-carbazole-4-carboxylic acid benzyl-methyl-amide

Guidance literature:: 9-(2-benzyloxy-ethyl)-2,3,4,9-tetrahydro-1H-carbazole-4-carboxylic acid; With oxalyl dichloride; In dichloromethane; at 0 - 20 ℃; for 3h; Inert atmosphere;

benzyl-methyl-amine; In dichloromethane; at 20 ℃;

Reference yield:

: 1462-37-9
bromoethyl-2-benzyl ether

: 1246453-83-7
9-(2-benzyloxy-ethyl)-2,3,4,9-tetrahydro-1H-carbazole-4-carboxylic acid benzyl-methyl-amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 2,6-dimethylpyridine / N,N-dimethyl-formamide / 100 °C

2.1: zinc(II) chloride / isopropyl alcohol / 19 h / 50 °C / Inert atmosphere; Reflux

3.1: sodium hydroxide / water; ethanol / 2 h / Reflux

4.1: oxalyl dichloride / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

4.2: 20 °C

With 2,6-dimethylpyridine; oxalyl dichloride; sodium hydroxide; zinc(II) chloride; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 1655-07-8
ethyl 2-oxocyclohexane carboxylate

: 1246453-83-7
9-(2-benzyloxy-ethyl)-2,3,4,9-tetrahydro-1H-carbazole-4-carboxylic acid benzyl-methyl-amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: bromine / diethyl ether; water / 1.75 h / 0 - 20 °C / Inert atmosphere

2.1: zinc(II) chloride / isopropyl alcohol / 19 h / 50 °C / Inert atmosphere; Reflux

3.1: sodium hydroxide / water; ethanol / 2 h / Reflux

4.1: oxalyl dichloride / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

4.2: 20 °C

With oxalyl dichloride; bromine; sodium hydroxide; zinc(II) chloride; In diethyl ether; ethanol; dichloromethane; water; isopropyl alcohol;