4-(4-methoxyphenyl)-1-methyl-5-oxo-5,7-dihydro-1H-furo-[3,4f][3,1]benzimidazol-3-ium chloride

Base Information

Chemical Name:4-(4-methoxyphenyl)-1-methyl-5-oxo-5,7-dihydro-1H-furo-[3,4f][3,1]benzimidazol-3-ium chloride
CAS No.:1572419-19-2
Molecular Formula:C₁₇H₁₄N₂O₃*ClH
Molecular Weight:330.771
Hs Code.:

Synonyms:4-(4-methoxyphenyl)-1-methyl-5-oxo-5,7-dihydro-1H-furo-[3,4f][3,1]benzimidazol-3-ium chloride

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Chemical Property of 4-(4-methoxyphenyl)-1-methyl-5-oxo-5,7-dihydro-1H-furo-[3,4f][3,1]benzimidazol-3-ium chloride

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Technology Process of 4-(4-methoxyphenyl)-1-methyl-5-oxo-5,7-dihydro-1H-furo-[3,4f][3,1]benzimidazol-3-ium chloride

There total 6 articles about 4-(4-methoxyphenyl)-1-methyl-5-oxo-5,7-dihydro-1H-furo-[3,4f][3,1]benzimidazol-3-ium chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1373395-15-3
4-(4-methoxyphenyl)-1-methyl-1,7-dihydro-furo[3,4-f]benzimidazol-5-one

: 1572419-19-2
4-(4-methoxyphenyl)-1-methyl-5-oxo-5,7-dihydro-1H-furo-[3,4f][3,1]benzimidazol-3-ium chloride

Guidance literature:: With (2-trimethylethylsilylethoxy)methyl chloride; In acetonitrile; at 60 ℃; for 1h;
DOI:10.1021/jo4027337

Reference yield:

: 2227-57-8
3-(4-methoxyphenyl)propynoic acid

: 1572419-19-2
4-(4-methoxyphenyl)-1-methyl-5-oxo-5,7-dihydro-1H-furo-[3,4f][3,1]benzimidazol-3-ium chloride

Guidance literature:: Multi-step reaction with 6 steps

1: dmap; (1S)-10-camphorsulfonic acid; dicyclohexyl-carbodiimide / dichloromethane / 2 h / -78 - 20 °C / Inert atmosphere

2: toluene / 48 h / 130 °C / Inert atmosphere; Sealed tube

3: manganese(IV) oxide / dichloromethane / 24 h / 20 °C

4: toluene / 24 h / 120 °C

5: sodium hydrogencarbonate; palladium 10% on activated carbon; hydrogen / ethanol / 24 h / 80 °C / 760.05 Torr

6: (2-trimethylethylsilylethoxy)methyl chloride / acetonitrile / 1 h / 60 °C

With dmap; manganese(IV) oxide; palladium 10% on activated carbon; (1S)-10-camphorsulfonic acid; hydrogen; (2-trimethylethylsilylethoxy)methyl chloride; sodium hydrogencarbonate; dicyclohexyl-carbodiimide; In ethanol; dichloromethane; toluene; acetonitrile;
DOI:10.1021/jo4027337

Reference yield:

: 1373395-14-2
(2E)-3-(1-benzyl-1H-imidazol-4-yl)prop-2-enyl 3-(4-methoxyphenyl)propynoate

: 1572419-19-2
4-(4-methoxyphenyl)-1-methyl-5-oxo-5,7-dihydro-1H-furo-[3,4f][3,1]benzimidazol-3-ium chloride

Guidance literature:: Multi-step reaction with 5 steps

1: toluene / 48 h / 130 °C / Inert atmosphere; Sealed tube

2: manganese(IV) oxide / dichloromethane / 24 h / 20 °C

3: toluene / 24 h / 120 °C

4: sodium hydrogencarbonate; palladium 10% on activated carbon; hydrogen / ethanol / 24 h / 80 °C / 760.05 Torr

5: (2-trimethylethylsilylethoxy)methyl chloride / acetonitrile / 1 h / 60 °C

With manganese(IV) oxide; palladium 10% on activated carbon; hydrogen; (2-trimethylethylsilylethoxy)methyl chloride; sodium hydrogencarbonate; In ethanol; dichloromethane; toluene; acetonitrile;
DOI:10.1021/jo4027337