6,9-ethano-4H-pyrido[1,2-a]pyrimidine-2-carboxamide, 9-amino-N-[(4-fluorophenyl)methyl]-6,7,8,9-tetrahydro-3-hydroxy-4-oxo-

Base Information

Chemical Name:6,9-ethano-4H-pyrido[1,2-a]pyrimidine-2-carboxamide, 9-amino-N-[(4-fluorophenyl)methyl]-6,7,8,9-tetrahydro-3-hydroxy-4-oxo-
CAS No.:1188424-46-5
Molecular Formula:C₁₈H₁₉FN₄O₃
Molecular Weight:358.372
Hs Code.:

Synonyms:6,9-ethano-4H-pyrido[1,2-a]pyrimidine-2-carboxamide, 9-amino-N-[(4-fluorophenyl)methyl]-6,7,8,9-tetrahydro-3-hydroxy-4-oxo-

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Chemical Property of 6,9-ethano-4H-pyrido[1,2-a]pyrimidine-2-carboxamide, 9-amino-N-[(4-fluorophenyl)methyl]-6,7,8,9-tetrahydro-3-hydroxy-4-oxo-

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Technology Process of 6,9-ethano-4H-pyrido[1,2-a]pyrimidine-2-carboxamide, 9-amino-N-[(4-fluorophenyl)methyl]-6,7,8,9-tetrahydro-3-hydroxy-4-oxo-

There total 1 articles about 6,9-ethano-4H-pyrido[1,2-a]pyrimidine-2-carboxamide, 9-amino-N-[(4-fluorophenyl)methyl]-6,7,8,9-tetrahydro-3-hydroxy-4-oxo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1188424-45-4
benzyl (2-((4-fluorobenzyl)carbamoyl)-3-hydroxy-4-oxo-7,8-dihydro-4H-6,9-ethanopyrido[1,2-a]pyrimidin-9(6H)-yl)carbamate

: 1188424-46-5
6,9-ethano-4H-pyrido[1,2-a]pyrimidine-2-carboxamide, 9-amino-N-[(4-fluorophenyl)methyl]-6,7,8,9-tetrahydro-3-hydroxy-4-oxo-

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethanol; for 18h; under 760.051 Torr;

Reference yield: 45.0%

: 1188424-46-5
6,9-ethano-4H-pyrido[1,2-a]pyrimidine-2-carboxamide, 9-amino-N-[(4-fluorophenyl)methyl]-6,7,8,9-tetrahydro-3-hydroxy-4-oxo-

: 75-36-5
acetyl chloride

: 1188424-47-6
6,9-Ethano-4H-pyrido[1,2-a]pyrimidine-2-carboxamide, 9-(acetylamino)-N-[(4-fluorophenyl)methyl]-6,7,8,9-tetrahydro-3-hydroxy-4-oxo-

Guidance literature:: 6,9-ethano-4H-pyrido[1,2-a]pyrimidine-2-carboxamide, 9-amino-N-[(4-fluorophenyl)methyl]-6,7,8,9-tetrahydro-3-hydroxy-4-oxo-; acetyl chloride; With triethylamine; In dichloromethane; at 20 ℃; for 16h;

With dimethyl amine; In methanol; at 60 ℃; for 2h;

Reference yield: 35.0%

: 32833-96-8
N,N-dimethyloxamic acid

: 1188424-46-5
6,9-ethano-4H-pyrido[1,2-a]pyrimidine-2-carboxamide, 9-amino-N-[(4-fluorophenyl)methyl]-6,7,8,9-tetrahydro-3-hydroxy-4-oxo-

: 1188424-51-2
Ethanediamide, N'-[2-[[[(4-fluorophenyl)methyl]amino]carbonyl]-7,8-dihydro-3-hydroxy-4-oxo-6,9-ethano-4H-pyrido[1,2-a]pyrimidin-9(6H)-yl]-N,N-dimethyl-

Guidance literature:: N,N-dimethyloxamic acid; With 4-methyl-morpholine; isopropyl chloroformate; In dichloromethane; toluene; at 20 ℃; for 2h;

6,9-ethano-4H-pyrido[1,2-a]pyrimidine-2-carboxamide, 9-amino-N-[(4-fluorophenyl)methyl]-6,7,8,9-tetrahydro-3-hydroxy-4-oxo-; In dichloromethane; toluene; at 20 ℃; for 16h;

With dimethyl amine; In methanol; at 60 ℃; for 2h;