[4-chloro-6-(2,2,2-trifluoro-ethoxy)-pyrimidin-2-yl]-(3-trifluoromethyl-phenyl)-amine

Base Information

• Chemical Name: [4-chloro-6-(2,2,2-trifluoro-ethoxy)-pyrimidin-2-yl]-(3-trifluoromethyl-phenyl)-amine
• CAS No.: 1251463-14-5
• Molecular Formula: C₁₃H₈ClF₆N₃O
• Molecular Weight: 371.669

Synonyms:[4-chloro-6-(2,2,2-trifluoro-ethoxy)-pyrimidin-2-yl]-(3-trifluoromethyl-phenyl)-amine

Chemical Property of [4-chloro-6-(2,2,2-trifluoro-ethoxy)-pyrimidin-2-yl]-(3-trifluoromethyl-phenyl)-amine

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Technology Process of [4-chloro-6-(2,2,2-trifluoro-ethoxy)-pyrimidin-2-yl]-(3-trifluoromethyl-phenyl)-amine

There total 1 articles about [4-chloro-6-(2,2,2-trifluoro-ethoxy)-pyrimidin-2-yl]-(3-trifluoromethyl-phenyl)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

2,2,2-trifluoroethanol (75-89-8) + (4,6-dichloro-pyrimidin-2-yl)-(3-trifluoromethyl-phenyl)-amine (1251463-13-4) → [4-chloro-6-(2,2,2-trifluoro-ethoxy)-pyrimidin-2-yl]-(3-trifluoromethyl-phenyl)-amine (1251463-14-5)

Guidance literature:

With potassium carbonate; for 6h; Reflux;

Reference yield: 70.0%

5-methylfurfurylamine (14003-16-8) + [4-chloro-6-(2,2,2-trifluoro-ethoxy)-pyrimidin-2-yl]-(3-trifluoromethyl-phenyl)-amine (1251463-14-5) → N-(5-methyl-furan-2-ylmethyl)-6-(2,2,2-trifluoro-ethoxy)-N'-(3-trifluoromethyl-phenyl)-pyrimidine-2,4-diamine

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide; at 90 ℃; for 1h;

Reference yield: 59.0%

[4-chloro-6-(2,2,2-trifluoro-ethoxy)-pyrimidin-2-yl]-(3-trifluoromethyl-phenyl)-amine (1251463-14-5) + C13H19N3O3S*ClH (1251463-30-5) → N-(3-{4-[6-(2,2,2-trifluoro-ethoxy)-2-(3-trifluoromethyl-phenylamino)-pyrimidin-4-ylamino]-piperidine-1-sulfonyl}-phenyl)-acetamide (1251463-18-9)

Guidance literature:

With sodium hydrogencarbonate; In dimethyl sulfoxide; at 140 ℃; for 1h;

upstream raw materials:

2,2,2-trifluoroethanol

(4,6-dichloro-pyrimidin-2-yl)-(3-trifluoromethyl-phenyl)-amine

Downstream raw materials:

N-[(5-methyl-isoxazol-3-yl)methyl]-6-(2,2,2-trifluoroethoxy)-N'-[3-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine

N-(4-{4-[6-(2,2,2-trifluoro-ethoxy)-2-(3-trifluoromethyl-phenylamino)-pyrimidin-4-ylamino]-piperidine-1-sulfonyl}-phenyl)-acetamide

N-(3-{4-[6-(2,2,2-trifluoro-ethoxy)-2-(3-trifluoromethyl-phenylamino)-pyrimidin-4-ylamino]-piperidine-1-sulfonyl}-phenyl)-acetamide

N-(1-benzenesulfonyl-piperidin-4-yl)-6-(2,2,2-trifluoro-ethoxy)-N'-(3-trifluoromethyl-phenyl)-pyrimidine-2,4-diamine

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