Tyr-gly-gly-phe-leu-arg

Base Information

• Chemical Name: Tyr-gly-gly-phe-leu-arg
• CAS No.: 75106-70-6
• Molecular Formula: C34H49 N9 O8
• Molecular Weight: 711.819
• UNII: V1PIQ8ZW62
• DSSTox Substance ID: DTXSID90996605
• Nikkaji Number: J293.206G
• ChEMBL ID: CHEMBL63188
• Mol file: 75106-70-6.mol

Synonyms:6-Arg-Leu-enkephalin;enkephalin-Leu, Arg(6)-;enkephalin-Leu, arginine(6)-;L-Arginine, N(2)-(N-(N-(N-(N-L-tyrosylglycyl)glycyl)-L-phenylalanyl)-L-leucyl)-;Leu-enkephalin, Arg(6)-;leucine-enkephalin, Arg(6)-;dynorphin (1-6);Tyr-Gly-Gly-Phe-Leu-Arg;tyrosyl-glycyl-glycyl-phenylalanyl-leucyl-arginine;tyrosyl-glycyl-glycyl-phenylalanyl-leucyl-arginine monoacetate, (L-Tyr-L-Phe-D-Leu-L-Arg)-isomer;tyrosyl-glycyl-glycyl-phenylalanyl-leucyl-arginine, (L-Tyr-L-Phe-D-Leu-L-Arg)-isomer

Chemical Property of Tyr-gly-gly-phe-leu-arg

Chemical Property:

• PSA: 290.95000
• Density: 1.37g/cm³
• LogP: 2.43120
• Storage Temp.: -15°C
• XLogP3: -3.8
• Hydrogen Bond Donor Count: 10
• Hydrogen Bond Acceptor Count: 10
• Rotatable Bond Count: 21
• Exact Mass: 711.37040956
• Heavy Atom Count: 51
• Complexity: 1180

Purity/Quality:

99% ^*data from raw suppliers

Dynorphin A (1-6) > 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)CC(C(=O)NC(CCCN=C(N)N)C(=O)O)NC(=O)C(CC1=CC=CC=C1)NC(=O)CNC(=O)CNC(=O)C(CC2=CC=C(C=C2)O)N
• Isomeric SMILES: CC(C)C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)CNC(=O)CNC(=O)[C@H](CC2=CC=C(C=C2)O)N

Technology Process of Tyr-gly-gly-phe-leu-arg

There total 1 articles about Tyr-gly-gly-phe-leu-arg which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Dynorphin 1-8 (75790-53-3) → tyrosylglycylglycine (21778-69-8) + LEU-ARG-ARG-ILE + dynorphin A(1-6) (75106-70-6)

Guidance literature:

With α-chymotrypsin; for 0.05h; Kinetics; Ambient temperature; NH₄OAc as buffer, pH 6.8;

DOI:10.1021/ja00195a012

Reference yield:

2-sulfobenzoic acid cyclic anhydride (81-08-3) + dynorphin A(1-6) (75106-70-6) → C41H53N9O12S

Guidance literature:

With TAPS buffer; In tetrahydrofuran; at 20 ℃; for 0.0833333h; pH=8.5;

DOI:10.1021/ac060760d

Reference yield:

dynorphin A(1-6) (75106-70-6) + 7-amino-4-methylcoumarin-3-acetic acid succinimidyl ester (113721-87-2) → C46H58N10O11

Guidance literature:

With sodium hydrogencarbonate; In water; dimethyl sulfoxide; at 20 ℃; for 0.175h; pH=8.5;

DOI:10.1021/ac071241t

upstream raw materials:

Dynorphin 1-8

Downstream raw materials:

YGGFLO

Refernces