Tyrosyl-glycyl-glycyl-phenylalanyl-leucyl-arginyl-arginyl-isoleucine

Base Information

Chemical Name:Tyrosyl-glycyl-glycyl-phenylalanyl-leucyl-arginyl-arginyl-isoleucine
CAS No.:75790-53-3
Molecular Formula:C46H72 N14 O10
Molecular Weight:981.165
Hs Code.:
Mol file:75790-53-3.mol

Synonyms:dynorphin (1-8);dynorphin A (1-8);L-Isoleucine, N-(N(2)-(N(2)-(N-(N-(N-(N-L-tyrosylglycyl)glycyl)-L-phenylalanyl)-L-leucyl)-L-arginyl)-L-arginyl)-;L-Isoleucine, N-(N2-(N2-(N-(N-(N-(N-L-tyrosylglycyl)glycyl)-L-phenylalanyl)-L-leucyl)-L-arginyl)-L-arginyl)-;PH-8P;Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile;tyrosyl-glycyl-glycyl-phenylalanyl--leucyl-arginyl-arginyl-isoleucine

Suppliers and Price of Tyrosyl-glycyl-glycyl-phenylalanyl-leucyl-arginyl-arginyl-isoleucine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Chem-Impex
DynorphinA(1-8)acetatesalt
5MG
$ 223.64

Chem-Impex
DynorphinA(1-8)acetatesalt
25MG
$ 895.73

Biorbyt Ltd
Dynorphin A (1-8) > 95%
5 mg
$ 552.50

Biorbyt Ltd
Dynorphin A (1-8) > 95%
1 mg
$ 287.30

Biorbyt Ltd
Dynorphin A (1-8) > 95%
10 mg
$ 708.90

American Custom Chemicals Corporation
DYNORPHIN A (1 - 8), PORCINE 95.00%
5MG
$ 730.54

American Custom Chemicals Corporation
DYNORPHIN A (1 - 8), PORCINE 95.00%
1MG
$ 583.34

Total 24 raw suppliers

Chemical Property of Tyrosyl-glycyl-glycyl-phenylalanyl-leucyl-arginyl-arginyl-isoleucine

Chemical Property:

PKA:3.38±0.10(Predicted)
PSA：411.05000
Density:1.38g/cm³
LogP:3.68290
Storage Temp.:−20°C
XLogP3:-3.7
Hydrogen Bond Donor Count:14
Hydrogen Bond Acceptor Count:13
Rotatable Bond Count:31
Exact Mass:980.55558455
Heavy Atom Count:70
Complexity:1760

Purity/Quality:

99%, ^*data from raw suppliers

DynorphinA(1-8)acetatesalt ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:CCC(C)C(C(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)CNC(=O)CNC(=O)C(CC2=CC=C(C=C2)O)N
Isomeric SMILES:CC[C@H](C)[C@@H](C(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)CNC(=O)CNC(=O)[C@H](CC2=CC=C(C=C2)O)N

Technology Process of Tyrosyl-glycyl-glycyl-phenylalanyl-leucyl-arginyl-arginyl-isoleucine

There total 3 articles about Tyrosyl-glycyl-glycyl-phenylalanyl-leucyl-arginyl-arginyl-isoleucine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 83731-82-2
H-Leu-Arg-Arg-Ile-N₂H₂Ph

: 75790-53-3
dynorphin A (1-8)

Guidance literature:: Multi-step reaction with 2 steps

1: 52 percent / dimethylformamide / 12 h / 37 °C / α-chymotrypsin, 0.2 M carbonate buffer pH 10.1

2: 1.) FeCl₃*6H₂O, 2.) TFA, HBr / 1.) water, dioxane, 36 deg C, 2.) anisole, 60 min

With hydrogen bromide; trifluoroacetic acid; In N,N-dimethyl-formamide;
DOI:10.1021/jo00148a014

Reference yield:

: 75488-73-2
Boc-Tyr(Bzl)-Gly-Gly-Phe-OEt

: 75790-53-3
dynorphin A (1-8)

Guidance literature:: Multi-step reaction with 2 steps

1: 52 percent / dimethylformamide / 12 h / 37 °C / α-chymotrypsin, 0.2 M carbonate buffer pH 10.1

2: 1.) FeCl₃*6H₂O, 2.) TFA, HBr / 1.) water, dioxane, 36 deg C, 2.) anisole, 60 min

With hydrogen bromide; trifluoroacetic acid; In N,N-dimethyl-formamide;
DOI:10.1021/jo00148a014

Reference yield:

: 83731-87-7
Boc-Tyr(Bzl)-Gly-Gly-Phe-Leu-Arg-Arg-Ile-N₂H₂Ph

: 75790-53-3
dynorphin A (1-8)

Guidance literature:: With hydrogen bromide; trifluoroacetic acid; Yield given. Multistep reaction; 1.) water, dioxane, 36 deg C, 2.) anisole, 60 min;
DOI:10.1021/jo00148a014