N-(3-aminopropoxy)-3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamide

Base Information

Chemical Name:N-(3-aminopropoxy)-3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamide
CAS No.:1596369-02-6
Molecular Formula:C₁₆H₁₅F₃IN₃O₂
Molecular Weight:465.214
Hs Code.:

Synonyms:N-(3-aminopropoxy)-3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(3-aminopropoxy)-3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamide

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Technology Process of N-(3-aminopropoxy)-3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamide

There total 1 articles about N-(3-aminopropoxy)-3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 391211-97-5
3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzoic acid

: 847609-99-8
3-(aminooxy)propylcarbamic acid tert-butyl ester

: 1596369-02-6
N-(3-aminopropoxy)-3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamide

Guidance literature:: 3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzoic acid; 3-(aminooxy)propylcarbamic acid tert-butyl ester; With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; at 20 ℃; for 10h;

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.5h;
DOI:10.3390/molecules181113957

Reference yield: 90.0%

: 108-30-5
succinic acid anhydride

: 1596369-02-6
N-(3-aminopropoxy)-3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamide

: 1596369-07-1
4-((3-((3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamido)oxy)propyl)amino)-4-oxobutanoic acid

Guidance literature:: With pyridine; at 20 ℃; for 1h;
DOI:10.3390/molecules181113957

Reference yield:

: 1596369-02-6
N-(3-aminopropoxy)-3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamide

: 1596369-16-2
2,5-dioxopyrrolidin-1-yl 4-((3-(3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamido)propyl)amino)-4-oxobutanoate

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / 1 h / 20 °C

2: dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 24 h / 20 °C

With pyridine; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide;
DOI:10.3390/molecules181113957