2,5-dioxopyrrolidin-1-yl 4-((3-(3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamido)propyl)amino)-4-oxobutanoate

Base Information

Chemical Name:2,5-dioxopyrrolidin-1-yl 4-((3-(3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamido)propyl)amino)-4-oxobutanoate
CAS No.:1596369-16-2
Molecular Formula:C₂₄H₂₂F₃IN₄O₇
Molecular Weight:662.361
Hs Code.:

Synonyms:2,5-dioxopyrrolidin-1-yl 4-((3-(3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamido)propyl)amino)-4-oxobutanoate

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Chemical Property of 2,5-dioxopyrrolidin-1-yl 4-((3-(3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamido)propyl)amino)-4-oxobutanoate

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Technology Process of 2,5-dioxopyrrolidin-1-yl 4-((3-(3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamido)propyl)amino)-4-oxobutanoate

There total 2 articles about 2,5-dioxopyrrolidin-1-yl 4-((3-(3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamido)propyl)amino)-4-oxobutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 6066-82-6
1-hydroxy-pyrrolidine-2,5-dione

: 1596369-07-1
4-((3-((3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamido)oxy)propyl)amino)-4-oxobutanoic acid

: 1596369-16-2
2,5-dioxopyrrolidin-1-yl 4-((3-(3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamido)propyl)amino)-4-oxobutanoate

Guidance literature:: With dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 20 ℃; for 24h;
DOI:10.3390/molecules181113957

Reference yield:

: 1596369-02-6
N-(3-aminopropoxy)-3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamide

: 1596369-16-2
2,5-dioxopyrrolidin-1-yl 4-((3-(3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamido)propyl)amino)-4-oxobutanoate

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / 1 h / 20 °C

2: dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 24 h / 20 °C

With pyridine; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide;
DOI:10.3390/molecules181113957