2-pyridin-2-yl-quinoline-4-carboxylic acid [3-(benzhydrylidene-amino)-propyl]-methyl-amide

Base Information

Chemical Name:2-pyridin-2-yl-quinoline-4-carboxylic acid [3-(benzhydrylidene-amino)-propyl]-methyl-amide
CAS No.:778647-51-1
Molecular Formula:C₃₂H₂₈N₄O
Molecular Weight:484.601
Hs Code.:

Synonyms:2-pyridin-2-yl-quinoline-4-carboxylic acid [3-(benzhydrylidene-amino)-propyl]-methyl-amide

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Chemical Property of 2-pyridin-2-yl-quinoline-4-carboxylic acid [3-(benzhydrylidene-amino)-propyl]-methyl-amide

Chemical Property:

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Technology Process of 2-pyridin-2-yl-quinoline-4-carboxylic acid [3-(benzhydrylidene-amino)-propyl]-methyl-amide

There total 2 articles about 2-pyridin-2-yl-quinoline-4-carboxylic acid [3-(benzhydrylidene-amino)-propyl]-methyl-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: N-benzhydrylidene-N'-methyl-propane-1,3-diamine

: 57882-27-6
2-(pyridin-2-yl)-quinoline-4-carboxylic acid

: 778647-51-1
2-pyridin-2-yl-quinoline-4-carboxylic acid [3-(benzhydrylidene-amino)-propyl]-methyl-amide

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide; at 20 ℃; for 20h;
DOI:10.1016/j.tet.2004.05.106

Reference yield:

: 1013-88-3
Benzophenone imine

: 778647-51-1
2-pyridin-2-yl-quinoline-4-carboxylic acid [3-(benzhydrylidene-amino)-propyl]-methyl-amide

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / CH₂Cl₂ / 24 h / 20 °C

2: 100 percent / EDC; HOBt / dimethylformamide / 20 h / 20 °C

With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2004.05.106

Reference yield:

: 778647-51-1
2-pyridin-2-yl-quinoline-4-carboxylic acid [3-(benzhydrylidene-amino)-propyl]-methyl-amide

: 778647-55-5
2-pyridin-2-yl-quinoline-4-carboxylic acid (3-cyclohexyliminomethyleneamino-propyl)-methyl-amide

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / aq. TFA / CH₂Cl₂; tetrahydrofuran / 2 h / 20 °C

2: 75 percent / triethylamine / CH₂Cl₂ / 30 h / 20 °C

3: 26 percent / polymer-supported Mukaiyama's reagent; triethylamine / dimethylformamide / 4 h / 45 °C

With polymer-supported Mukaiyama's reagent; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2004.05.106