1-[(4-fluorophenyl)(1-isopropylpiperidin-4-yl)acetyl]-4-[4-(2-methoxy-1-naphthyl)butyl]piperazine

Base Information

Chemical Name:1-[(4-fluorophenyl)(1-isopropylpiperidin-4-yl)acetyl]-4-[4-(2-methoxy-1-naphthyl)butyl]piperazine
CAS No.:385844-27-9
Molecular Formula:C₃₅H₄₆FN₃O₂
Molecular Weight:559.768
Hs Code.:

Synonyms:1-[(4-fluorophenyl)(1-isopropylpiperidin-4-yl)acetyl]-4-[4-(2-methoxy-1-naphthyl)butyl]piperazine

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Chemical Property of 1-[(4-fluorophenyl)(1-isopropylpiperidin-4-yl)acetyl]-4-[4-(2-methoxy-1-naphthyl)butyl]piperazine

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Technology Process of 1-[(4-fluorophenyl)(1-isopropylpiperidin-4-yl)acetyl]-4-[4-(2-methoxy-1-naphthyl)butyl]piperazine

There total 9 articles about 1-[(4-fluorophenyl)(1-isopropylpiperidin-4-yl)acetyl]-4-[4-(2-methoxy-1-naphthyl)butyl]piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1-[(4-fluorophenyl)(piperidin-4-yl)acetyl]-4-[4-(2-methoxy-1-naphthyl)butyl]piperazine dihydrochloride

: 75-30-9
2-iodo-propane

: 385844-27-9
1-[(4-fluorophenyl)(1-isopropylpiperidin-4-yl)acetyl]-4-[4-(2-methoxy-1-naphthyl)butyl]piperazine

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 15h;
DOI:10.1016/j.bmc.2007.01.019

Reference yield:

: 1-[(4-fluorophenyl)(piperidin-4-yl)acetyl]-4-[4-(2-methoxy-1-naphthyl)butyl]piperazine dihydrochloride

: 75-30-9
2-iodo-propane

: 4-(1-(4-Fluorophenyl)-2-{4-[4-(2-methoxynaphthalen-1-yl)butyl]piperazin-1-yl}-2-oxoethyl)piperidine hydrochloride

: 385844-27-9
1-[(4-fluorophenyl)(1-isopropylpiperidin-4-yl)acetyl]-4-[4-(2-methoxy-1-naphthyl)butyl]piperazine

Guidance literature:: With potassium carbonate; In N-methyl-acetamide;

Reference yield:

: (4-fluoro-phenyl)-(1,2,3,6-tetrahydro-pyridin-4-yl)-acetic acid

: 385844-27-9
1-[(4-fluorophenyl)(1-isopropylpiperidin-4-yl)acetyl]-4-[4-(2-methoxy-1-naphthyl)butyl]piperazine

Guidance literature:: Multi-step reaction with 5 steps

1: 18.0 g / NaOH / CHCl₃; H₂O; dioxane / 0.5 h / 20 °C

2: 72 percent / hydrogen / Pd(OH)2/C / methanol / 48 h / 20 °C

3: 73 percent / 1-hydroxybenzotriazole hydrate; triethylamine; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / dimethylformamide / 15 h / 20 °C

4: 85 percent / hydrochloric acid / methanol; dioxane / 2 h / 20 °C

5: 78 percent / K₂CO₃ / dimethylformamide / 15 h / 20 °C

With hydrogenchloride; sodium hydroxide; hydrogen; potassium carbonate; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium dihydroxide; In 1,4-dioxane; methanol; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2007.01.019