(2S,6R)-6-(3,3-Dibromo-allyl)-2-[(R)-3-(4-methoxy-benzyloxy)-2-methyl-propyl]-3,6-dihydro-2H-pyran

Base Information

Chemical Name:(2S,6R)-6-(3,3-Dibromo-allyl)-2-[(R)-3-(4-methoxy-benzyloxy)-2-methyl-propyl]-3,6-dihydro-2H-pyran
CAS No.:856410-64-5
Molecular Formula:C₂₀H₂₆Br₂O₃
Molecular Weight:474.233
Hs Code.:

Synonyms:(2S,6R)-6-(3,3-Dibromo-allyl)-2-[(R)-3-(4-methoxy-benzyloxy)-2-methyl-propyl]-3,6-dihydro-2H-pyran

Suppliers and Price of (2S,6R)-6-(3,3-Dibromo-allyl)-2-[(R)-3-(4-methoxy-benzyloxy)-2-methyl-propyl]-3,6-dihydro-2H-pyran

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S,6R)-6-(3,3-Dibromo-allyl)-2-[(R)-3-(4-methoxy-benzyloxy)-2-methyl-propyl]-3,6-dihydro-2H-pyran

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,6R)-6-(3,3-Dibromo-allyl)-2-[(R)-3-(4-methoxy-benzyloxy)-2-methyl-propyl]-3,6-dihydro-2H-pyran

There total 9 articles about (2S,6R)-6-(3,3-Dibromo-allyl)-2-[(R)-3-(4-methoxy-benzyloxy)-2-methyl-propyl]-3,6-dihydro-2H-pyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 558-13-4
carbon tetrabromide

: 259199-01-4
{(2R)-6-[3-(4-methoxybenzyloxy)-2-methyl-propyl]-(2R,6S)-5,6-dihydro-2H-pyran-2-yl}acetaldehyde

: 856410-64-5
(2S,6R)-6-(3,3-Dibromo-allyl)-2-[(R)-3-(4-methoxy-benzyloxy)-2-methyl-propyl]-3,6-dihydro-2H-pyran

Guidance literature:: With triphenylphosphine; In dichloromethane; at 0 ℃;
DOI:10.1002/anie.200500029

Reference yield:

: 856410-62-3
Benzoic acid (E)-(7R,9R)-7-(tert-butyl-dimethyl-silanyloxy)-10-(4-methoxy-benzyloxy)-9-methyl-5-oxo-dec-3-enyl ester

: 856410-64-5
(2S,6R)-6-(3,3-Dibromo-allyl)-2-[(R)-3-(4-methoxy-benzyloxy)-2-methyl-propyl]-3,6-dihydro-2H-pyran

Guidance literature:: Multi-step reaction with 6 steps

1.1: 99 percent / BH₃*THF; (S)-Corey-Bakshi-Shibata oxazaborolidine reagent / tetrahydrofuran / -40 °C

2.1: 85 percent / TBAF / tetrahydrofuran / 20 °C

3.1: PdCl₂(CH₃CN)2 / tetrahydrofuran / 1 h / -5 °C

3.2: 60 percent / benzoquinone / tetrahydrofuran / 48 h / 20 °C

4.1: 92 percent / K₂CO₃ / methanol / 20 °C

5.1: 91 percent / Dess-Martin periodinane

6.1: 94 percent / PPh₃ / CH₂Cl₂ / 0 °C

With borane-THF; (S)-Corey-Bakshi-Shibata oxazaborolidine reagent; tetrabutyl ammonium fluoride; potassium carbonate; Dess-Martin periodane; triphenylphosphine; dichloro bis(acetonitrile) palladium(II); In tetrahydrofuran; methanol; dichloromethane; 5.1: Dess-Martin oxidation;
DOI:10.1002/anie.200500029

Reference yield:

: 259198-98-6
(4S,6R)-7-(p-methoxybenzyloxy)-6-methylhept-1-en-4-ol

: 856410-64-5
(2S,6R)-6-(3,3-Dibromo-allyl)-2-[(R)-3-(4-methoxy-benzyloxy)-2-methyl-propyl]-3,6-dihydro-2H-pyran

Guidance literature:: Multi-step reaction with 9 steps

1.1: 97 percent / imidazole / dimethylformamide / 20 °C

2.1: OsO₄; NMO / tetrahydrofuran; H₂O / 20 °C

2.2: NaIO₄ / tetrahydrofuran; H₂O

2.3: 75 percent / NiCl₂; CrCl₂ / dimethylsulfoxide / 20 °C

3.1: 91 percent / Dess-Martin periodinane

4.1: 99 percent / BH₃*THF; (S)-Corey-Bakshi-Shibata oxazaborolidine reagent / tetrahydrofuran / -40 °C

5.1: 85 percent / TBAF / tetrahydrofuran / 20 °C

6.1: PdCl₂(CH₃CN)2 / tetrahydrofuran / 1 h / -5 °C

6.2: 60 percent / benzoquinone / tetrahydrofuran / 48 h / 20 °C

7.1: 92 percent / K₂CO₃ / methanol / 20 °C

8.1: 91 percent / Dess-Martin periodinane

9.1: 94 percent / PPh₃ / CH₂Cl₂ / 0 °C

With 1H-imidazole; osmium(VIII) oxide; N-methyl-2-indolinone; borane-THF; (S)-Corey-Bakshi-Shibata oxazaborolidine reagent; tetrabutyl ammonium fluoride; potassium carbonate; Dess-Martin periodane; triphenylphosphine; dichloro bis(acetonitrile) palladium(II); In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; 3.1: Dess-Martin oxidation / 8.1: Dess-Martin oxidation;
DOI:10.1002/anie.200500029