259199-01-4

Basic information

• Product Name: {(2R)-6-[3-(4-methoxybenzyloxy)-2-methyl-propyl]-(2R,6S)-5,6-dihydro-2H-pyran-2-yl}acetaldehyde
• Synonyms: {(2R)-6-[3-(4-methoxybenzyloxy)-2-methyl-propyl]-(2R,6S)-5,6-dihydro-2H-pyran-2-yl}acetaldehyde
• CAS NO: 259199-01-4
• Molecular Weight: 318.413
• Mol File: 259199-01-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: {(2R)-6-[3-(4-methoxybenzyloxy)-2-methyl-propyl]-(2R,6S)-5,6-dihydro-2H-pyran-2-yl}acetaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: {(2R)-6-[3-(4-methoxybenzyloxy)-2-methyl-propyl]-(2R,6S)-5,6-dihydro-2H-pyran-2-yl}acetaldehyde(259199-01-4)
• EPA Substance Registry System: {(2R)-6-[3-(4-methoxybenzyloxy)-2-methyl-propyl]-(2R,6S)-5,6-dihydro-2H-pyran-2-yl}acetaldehyde(259199-01-4)

Safety Data

• Hazardous Substances Data: 259199-01-4(Hazardous Substances Data)

Upstream product

• 66031-93-4 tert-butyldimethylsilyl vinyl ether 
• 259199-00-3 (2S,6RS)-7-ethoxy-2-[(2R)-3-(4-methoxybenzyloxy)-2-methylpropyl]-3,6-dihydro-2H-pyran 
• 259198-99-7 (4S,6R)-4-(1-ethoxyallyloxy)-7-(p-methoxybenzyloxy)-6-methylhept-1-ene 
• 527743-00-6 4-methyl-benzenesulfonic acid (S)-3-(4-methoxy-benzyloxy)-2-methyl-propyl ester 
• 259198-96-4 (3R)-4-(4-methoxybenzyloxy)-3-methylbutyrnitrile 
• 259198-97-5 (3R)-4-(4-methoxybenzyloxy)-3-methylbutyraldehyde 
• 136320-64-4 (2R)-3-[(4-methoxybenzyl)oxy]-2-methylpropanol 
• 856410-60-1 tert-Butyl-{(S)-1-[(R)-3-(4-methoxy-benzyloxy)-2-methyl-propyl]-but-3-enyloxy}-dimethyl-silane 
• 445306-72-9 (2R,6S)-2-{(2R)-6-[3-(4-methoxybenzyloxy)-2-methylpropyl]-5,6-dihydro-2H-pyran-2-yl}-ethanol 
• 259198-98-6 (4S,6R)-7-(p-methoxybenzyloxy)-6-methylhept-1-en-4-ol 
• 856410-62-3 Benzoic acid (E)-(7R,9R)-7-(tert-butyl-dimethyl-silanyloxy)-10-(4-methoxy-benzyloxy)-9-methyl-5-oxo-dec-3-enyl ester 
• 856410-43-0 Benzoic acid (E)-(7R,9R)-7-(tert-butyl-dimethyl-silanyloxy)-5-hydroxy-10-(4-methoxy-benzyloxy)-9-methyl-dec-3-enyl ester 
• 856410-63-4 Benzoic acid (E)-(5R,7R,9R)-7-(tert-butyl-dimethyl-silanyloxy)-5-hydroxy-10-(4-methoxy-benzyloxy)-9-methyl-dec-3-enyl ester 
• 856410-44-1 Benzoic acid (E)-(5R,7R,9R)-5,7-dihydroxy-10-(4-methoxy-benzyloxy)-9-methyl-dec-3-enyl ester 

Downstream Products

• 856410-65-6 4-{(2R,6S)-6-[(R)-3-(4-Methoxy-benzyloxy)-2-methyl-propyl]-5,6-dihydro-2H-pyran-2-yl}-but-2-yn-1-ol 
• 856410-66-7 3-{6-[4-(tert-butoxy-diphenyl-silanyloxy)-but-2-ynyl]-3,6-dihydro-2H-pyran-2-yl}-2-methyl-propan-1-ol 
• 856410-47-4 tert-butoxy-{4-[6-(4,4-dibromo-2-methyl-but-3-enyl)-5,6-dihydro-2H-pyran-2-yl]-but-2-ynyloxy}-diphenyl-silane 
• 856410-46-3 tert-butoxy-(4-{6-[3-(4-methoxy-benzyloxy)-2-methyl-propyl]-5,6-dihydro-2H-pyran-2-yl}-but-2-ynyloxy)-diphenyl-silane 
• 115268-43-4 laulimalide 
• 312695-81-1 4-(3-{6-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-3,6-dihydro-2H-pyran-2-yl}-2-methyl-propyl)-1-(4-methoxy-benzyloxy)-pent-4-en-2-ol 
• 385809-16-5 (2R,6R)-tert-butyl-[2-(6-{4-[(2S)-3-(4-methoxybenzyloxy)-2-methoxymethoxy-propyl]-[(2S)-2-methylpent-4-enyl]}-5,6-dihydro-2H-pyran-2-yl)-ethoxy]-dimethylsilane 
• 385809-13-2 [2R,(2R),6R]-{2-[6-(4-benzenesulfonyl-2-methylbutyl)-5,6-dihydro-2H-pyran-2-yl]ethoxy}-tert-butyldimethylsilane 
• 385809-14-3 (2S,4RS,6R)-4-benzenesulfonyl-7-{(2R,6R)-6-[2-(tert-butyldimethylsilanyloxy)-ethyl]-3,6-dihydro-2H-pyran-2-yl}-1-(4-methoxybenzyloxy)-6-methylheptan-2-ol 
• 385809-15-4 (2S,4RS,6S)-(2-{(2R,6R)-6-[4-benzenesulfonyl-7-(4-methoxybenzyloxy)-6-methoxymethoxy-2-methylheptyl]-5,6-dihydro-2H-pyran-2-yl}-ethoxy)-tert-butyldimethylsilane 
• 385809-24-5 [(2S),(2S,6S,7E,10S,11S,12E),(2R,6R)]-tert-butyl-(2-{6-[10-(4-methoxybenzyloxy)-6,11-bismethoxymethoxy-2-methyl-13-(4-methyl-3,6-dihydro-2H-pyran-2-yl)-4-methylenetrideca-7,12-dienyl]-5,6-dihydro-2H-pyran-2-yl}ethoxy)-dimethylsilane 
• 445306-73-0 (2R,6S)-tert-butyl-(2-{6-[(2R)-3-(4-methoxybenzyloxy)-2-methylpropyl]-5,6-dihydro-2H-pyran-2-yl}-ethoxy)-dimethylsilane 
• 527743-03-9 toluene-4-sulfonic acid 3-{6-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-3,6-dihydro-2H-pyran-2-yl}-2-methyl-propyl ester 
• 445306-65-0 2-(3-{6-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-3,6-dihydro-2H-pyran-2-yl}-2-methyl-propyl)-8-(tert-butyl-diphenyl-silanyloxy)-9-methoxymethoxy-11-(4-methyl-3,6-dihydro-2H-pyran-2-yl)-undeca-1,5,10-trien-4-ol 

Relevant articles and documents

Total synthesis of (-)-laulimalide: Pd-catalyzed stereospecific ring construction of the substituted 3,6-dihydro[2H]pyran units

(Chemical Equation Presented) The potent anticancer agent (-)-laulimalide (1) was prepared through a versatile method that should allow access to other marine natural products. Key steps included a Pd-catalyzed 1,3 chirality transfer of an allylic alcohol

Synthesis of the C1-C12-dihydropyran segment of the antitumor agent laulimalide by ring closing metathesis

A stereocontrolled synthesis of the C1-C12 fragment 3 of laulimalide utilizing a ring closing metathesis with Grubbs' catalyst as the key step is described.