Methyl 2-chloro-3-hydroxy-2-methyl-3-phenylpropanoate

Base Information

Chemical Name:Methyl 2-chloro-3-hydroxy-2-methyl-3-phenylpropanoate
CAS No.:80532-67-8
Molecular Formula:C₁₁H₁₃ClO₃
Molecular Weight:228.675
Hs Code.:
DSSTox Substance ID:DTXSID601222356

Synonyms:80532-67-8;DTXSID601222356;Methyl alpha-chloro-beta-hydroxy-alpha-methylbenzenepropanoate

Suppliers and Price of Methyl 2-chloro-3-hydroxy-2-methyl-3-phenylpropanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Methyl 2-chloro-3-hydroxy-2-methyl-3-phenylpropanoate

Chemical Property:

XLogP3:1.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:228.0553220
Heavy Atom Count:15
Complexity:226

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C(C1=CC=CC=C1)O)(C(=O)OC)Cl

Technology Process of Methyl 2-chloro-3-hydroxy-2-methyl-3-phenylpropanoate

There total 4 articles about Methyl 2-chloro-3-hydroxy-2-methyl-3-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 17640-02-7
methyl 2,2-dichloropropionate

: 100-52-7
benzaldehyde

: 80-63-7
methyl 2-chloroacrylate

: 80532-67-8
methyl 2-chloro-3-hydroxy-2-methyl-3-phenylpropanoate

Guidance literature:: With boron trifluoride; zinc; In tetrahydrofuran; at 0 ℃; for 24h;
DOI:10.1080/00397919608004648

Reference yield:

: 100-52-7
benzaldehyde

: 166666-36-0
methyl-α-bromo-α-chloro-propanoate

: 80-63-7
methyl 2-chloroacrylate

: 80532-67-8
methyl 2-chloro-3-hydroxy-2-methyl-3-phenylpropanoate

: dimethyl 2,3-dichloro-2,3-dimethylbutanedioate

Guidance literature:: With boron trifluoride; zinc; In tetrahydrofuran; at 0 ℃; for 3h;
DOI:10.1080/00397919608004648

Reference yield:

: 100-52-7
benzaldehyde

: 80532-67-8
methyl 2-chloro-3-hydroxy-2-methyl-3-phenylpropanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) LDA / 1.) THF, hexane, -80 deg C, 5 min, 2.) 5 min

2: CH₂Cl₂

With lithium diisopropyl amide; In dichloromethane;
DOI:10.1021/jo00346a013