1-(1,1-dimethylethyl) 3-methyl 4-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-5,5-dimethyl-2-oxo-1,3-pyrrolidinedicarboxylate

Base Information

Chemical Name:1-(1,1-dimethylethyl) 3-methyl 4-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-5,5-dimethyl-2-oxo-1,3-pyrrolidinedicarboxylate
CAS No.:1301660-91-2
Molecular Formula:C₃₈H₄₀F₇N₃O₆
Molecular Weight:767.741
Hs Code.:

1-(1,1-dimethylethyl) 3-methyl 4-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-5,5-dimethyl-2-oxo-1,3-pyrrolidinedicarboxylate

Synonyms:1-(1,1-dimethylethyl) 3-methyl 4-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-5,5-dimethyl-2-oxo-1,3-pyrrolidinedicarboxylate

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Chemical Property of 1-(1,1-dimethylethyl) 3-methyl 4-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-5,5-dimethyl-2-oxo-1,3-pyrrolidinedicarboxylate

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Technology Process of 1-(1,1-dimethylethyl) 3-methyl 4-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-5,5-dimethyl-2-oxo-1,3-pyrrolidinedicarboxylate

There total 7 articles about 1-(1,1-dimethylethyl) 3-methyl 4-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-5,5-dimethyl-2-oxo-1,3-pyrrolidinedicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1301660-89-8
1,1-dimethylethyl 3-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-2,2-dimethyl-5-oxo-1-pyrrolidinecarboxylate

: 79-22-1
methyl chloroformate

: 1301660-91-2
1-(1,1-dimethylethyl) 3-methyl 4-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-5,5-dimethyl-2-oxo-1,3-pyrrolidinedicarboxylate

Guidance literature:: 1,1-dimethylethyl 3-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-2,2-dimethyl-5-oxo-1-pyrrolidinecarboxylate; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.5h;

methyl chloroformate; In tetrahydrofuran; at -78 ℃; for 1h;

Reference yield:

: 825643-73-0
2-(3,5-bis(trifluoromethyl)phenyl)-N-(6-chloro-4-(4-fluoro-2-methylphenyl)pyridin-3-yl)-N,2-dimethylpropanamide

: 1301660-91-2
1-(1,1-dimethylethyl) 3-methyl 4-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-5,5-dimethyl-2-oxo-1,3-pyrrolidinedicarboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 8 h / Reflux

2.1: osmium(VIII) oxide; water / tetrahydrofuran / 0.5 h / 20 °C

2.2: 4 h / 20 °C

3.1: toluene / 2 h / Reflux

4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 0 - 20 °C

5.1: acetic acid; iron / ethanol; water / 60 - 75 °C

6.1: dmap; triethylamine / dichloromethane / 20 °C

7.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C

7.2: 1 h / -78 °C

With dmap; osmium(VIII) oxide; water; iron; sodium carbonate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; lithium hexamethyldisilazane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; toluene; 1.1: Suzuki Coupling;

Reference yield:

: 1301660-56-9
2-[3,5-bis(trifluoromethyl)phenyl]-N-[4-(4-fluoro-2-methylphenyl)-6-formyl-3-pyridinyl]-N,2-dimethylpropanamide

: 1301660-91-2
1-(1,1-dimethylethyl) 3-methyl 4-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-5,5-dimethyl-2-oxo-1,3-pyrrolidinedicarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: toluene / 2 h / Reflux

2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 0 - 20 °C

3.1: acetic acid; iron / ethanol; water / 60 - 75 °C

4.1: dmap; triethylamine / dichloromethane / 20 °C

5.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C

5.2: 1 h / -78 °C

With dmap; iron; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; dichloromethane; water; toluene;