(R)-1-(6-(3-fluoro-4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone trifluoroacetate

Base Information

Chemical Name:(R)-1-(6-(3-fluoro-4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone trifluoroacetate
CAS No.:1181692-22-7
Molecular Formula:C₂HF₃O₂*C₂₄H₂₉FN₂O
Molecular Weight:494.529
Hs Code.:

Synonyms:(R)-1-(6-(3-fluoro-4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone trifluoroacetate

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Chemical Property of (R)-1-(6-(3-fluoro-4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone trifluoroacetate

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Technology Process of (R)-1-(6-(3-fluoro-4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone trifluoroacetate

There total 8 articles about (R)-1-(6-(3-fluoro-4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1147392-15-1
(R)-3-fluoro-4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl trifluoromethanesulfonate

: 1181691-47-3
1-(6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone

: 1181692-22-7
(R)-1-(6-(3-fluoro-4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone trifluoroacetate

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; benzene; at 120 ℃; for 1h;

Reference yield:

: 1147392-09-3
(R)-1-(2-fluoro-4-methoxyphenethyl)-2-methylpyrrolidine

: 1181692-22-7
(R)-1-(6-(3-fluoro-4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1: boron tribromide / dichloromethane / 1 h / 20 °C

2: pyridine / dichloromethane / 1 h

3: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; benzene / 1 h / 120 °C

With pyridine; boron tribromide; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; dichloromethane; benzene; 3: Suzuki Coupling;

Reference yield:

: 883531-28-0
2-(2-fluoro-4-methoxyphenyl)acetic acid

: 1181692-22-7
(R)-1-(6-(3-fluoro-4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone trifluoroacetate

Guidance literature:: Multi-step reaction with 6 steps

1: borane-THF / tetrahydrofuran / 0 - 20 °C

2: triethylamine / dichloromethane / 20 °C / Ice cooling

3: potassium carbonate / acetonitrile / 60 °C

4: boron tribromide / dichloromethane / 1 h / 20 °C

5: pyridine / dichloromethane / 1 h

6: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; benzene / 1 h / 120 °C

With pyridine; borane-THF; boron tribromide; sodium carbonate; potassium carbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile; benzene; 6: Suzuki Coupling;