(R)-3-fluoro-4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl trifluoromethanesulfonate

Base Information

Chemical Name:(R)-3-fluoro-4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl trifluoromethanesulfonate
CAS No.:1147392-15-1
Molecular Formula:C₁₄H₁₇F₄NO₃S
Molecular Weight:355.353
Hs Code.:

Synonyms:(R)-3-fluoro-4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl trifluoromethanesulfonate

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Chemical Property of (R)-3-fluoro-4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl trifluoromethanesulfonate

Chemical Property:

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Technology Process of (R)-3-fluoro-4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl trifluoromethanesulfonate

There total 5 articles about (R)-3-fluoro-4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 358-23-6
trifluoromethylsulfonic anhydride

: 1147392-11-7
(R)-3-fluoro-4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenol

: 1147392-15-1
(R)-3-fluoro-4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl trifluoromethanesulfonate

Guidance literature:: With pyridine; In acetonitrile; at 0 ℃; for 2h;

Reference yield:

: 883531-28-0
2-(2-fluoro-4-methoxyphenyl)acetic acid

: 1147392-15-1
(R)-3-fluoro-4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 5 steps

1: borane-THF / tetrahydrofuran / 0 - 20 °C

2: triethylamine / dichloromethane / 20 °C / Ice cooling

3: potassium carbonate / acetonitrile / 60 °C

4: boron tribromide / dichloromethane / 1 h / 20 °C

5: pyridine / dichloromethane / 1 h

With pyridine; borane-THF; boron tribromide; potassium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; acetonitrile;

Reference yield:

: 1147392-04-8
2-(2-fluoro-4-methoxyphenyl)ethanol

: 1147392-15-1
(R)-3-fluoro-4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 20 °C / Ice cooling

2: potassium carbonate / acetonitrile / 60 °C

3: boron tribromide / dichloromethane / 1 h / 20 °C

4: pyridine / dichloromethane / 1 h

With pyridine; boron tribromide; potassium carbonate; triethylamine; In dichloromethane; acetonitrile;