[2-(tert-butyl-dimethyl-silanyloxy)-5-methoxy-phenyl]-(3,4,5-trimethoxy-phenyl)-methanol

Base Information

• Chemical Name: [2-(tert-butyl-dimethyl-silanyloxy)-5-methoxy-phenyl]-(3,4,5-trimethoxy-phenyl)-methanol
• CAS No.: 1027907-78-3
• Molecular Formula: C₂₃H₃₄O₆Si
• Molecular Weight: 434.605
• Mol file: 1027907-78-3.mol

Synonyms:[2-(tert-butyl-dimethyl-silanyloxy)-5-methoxy-phenyl]-(3,4,5-trimethoxy-phenyl)-methanol

Chemical Property of [2-(tert-butyl-dimethyl-silanyloxy)-5-methoxy-phenyl]-(3,4,5-trimethoxy-phenyl)-methanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [2-(tert-butyl-dimethyl-silanyloxy)-5-methoxy-phenyl]-(3,4,5-trimethoxy-phenyl)-methanol

There total 1 articles about [2-(tert-butyl-dimethyl-silanyloxy)-5-methoxy-phenyl]-(3,4,5-trimethoxy-phenyl)-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-bromo-3,4,5-trimethoxybenzene (2675-79-8) + 2-tert-butyldimethylsiloxy-5-methoxyphenyl carboxaldehyde (441068-94-6) → [2-(tert-butyl-dimethyl-silanyloxy)-5-methoxy-phenyl]-(3,4,5-trimethoxy-phenyl)-methanol (1027907-78-3)

Guidance literature:

1-bromo-3,4,5-trimethoxybenzene; With magnesium; In tetrahydrofuran; at 25 ℃; for 1h;

2-tert-butyldimethylsiloxy-5-methoxyphenyl carboxaldehyde; In tetrahydrofuran; at 25 ℃; for 0.333333h; Further stages.;

DOI:10.1021/jm010365+

Reference yield:

[2-(tert-butyl-dimethyl-silanyloxy)-5-methoxy-phenyl]-(3,4,5-trimethoxy-phenyl)-methanol (1027907-78-3) → [2-(tert-butyl-dimethyl-silanyloxy)-5-methoxy-phenyl]-(3,4,5-trimethoxy-phenyl)-methanone

Guidance literature:

With dipyridinium dichromate; In dichloromethane; at 25 ℃; for 8h;

DOI:10.1021/jm010365+

Reference yield:

[2-(tert-butyl-dimethyl-silanyloxy)-5-methoxy-phenyl]-(3,4,5-trimethoxy-phenyl)-methanol (1027907-78-3) → (2-hydroxy-5-methoxy-phenyl)-(3,4,5-trimethoxy-phenyl)-methanone

Guidance literature:

Multi-step reaction with 2 steps

1: pyridinium dichromate / CH₂Cl₂ / 8 h / 25 °C

2: Bu₄NF / tetrahydrofuran / 1 h / 25 °C

With dipyridinium dichromate; tetrabutyl ammonium fluoride; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm010365+

upstream raw materials:

1-bromo-3,4,5-trimethoxybenzene

2-tert-butyldimethylsiloxy-5-methoxyphenyl carboxaldehyde