2-tert-butyldimethylsiloxy-5-methoxyphenyl carboxaldehyde

Base Information

• Chemical Name: 2-tert-butyldimethylsiloxy-5-methoxyphenyl carboxaldehyde
• CAS No.: 441068-94-6
• Molecular Formula: C₁₄H₂₂O₃Si
• Molecular Weight: 266.412
• Mol file: 441068-94-6.mol

Synonyms:2-tert-butyldimethylsiloxy-5-methoxyphenyl carboxaldehyde

Chemical Property of 2-tert-butyldimethylsiloxy-5-methoxyphenyl carboxaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 2-tert-butyldimethylsiloxy-5-methoxyphenyl carboxaldehyde

There total 1 articles about 2-tert-butyldimethylsiloxy-5-methoxyphenyl carboxaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-hydroxy-5-methoxybenzaldehyde (672-13-9) + tert-butyldimethylsilyl chloride (18162-48-6) → 2-tert-butyldimethylsiloxy-5-methoxyphenyl carboxaldehyde (441068-94-6)

Guidance literature:

With 1H-imidazole; In dichloromethane; at 25 ℃; for 16h; Inert atmosphere;

DOI:10.1021/jm100531u

Reference yield: 96.0%

2-tert-butyldimethylsiloxy-5-methoxyphenyl carboxaldehyde (441068-94-6) → (2-((tert-butyldimethylsilyl)oxy)-5-methoxyphenyl)methanol (736985-95-8)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1021/jm100531u

Reference yield: 85.0%

trimethylsilylacetylene (1066-54-2) + 2-tert-butyldimethylsiloxy-5-methoxyphenyl carboxaldehyde (441068-94-6) → 1-(2-((tert-butyldimethylsilyl)oxy)-5-methoxyphenyl)-3-(trimethylsilyl)prop-2-yn-1-ol

Guidance literature:

With n-butyllithium; In tetrahydrofuran; at -78 - -40 ℃; Inert atmosphere;

DOI:10.1021/acs.joc.5b00384

upstream raw materials:

2-hydroxy-5-methoxybenzaldehyde

tert-butyldimethylsilyl chloride

Downstream raw materials:

[2-(tert-butyl-dimethyl-silanyloxy)-5-methoxy-phenyl]-(3,4,5-trimethoxy-phenyl)-methanol

(2-((tert-butyldimethylsilyl)oxy)-5-methoxyphenyl)methanol

2-hydroxy-5-methoxybenzyl vinyl ether

2-(tert-butyldimethylsilanyloxy)-5-methoxybenzyl vinyl ether