1-(2'-bromo-5'-hydroxybenzyl)-6,7-dimethoxy-5-hydroxy-3,4-dihydroisoquinoline hydrochloride

Base Information

Chemical Name:1-(2'-bromo-5'-hydroxybenzyl)-6,7-dimethoxy-5-hydroxy-3,4-dihydroisoquinoline hydrochloride
CAS No.:121949-70-0
Molecular Formula:C₁₈H₁₈BrNO₄*ClH
Molecular Weight:428.71
Hs Code.:

Synonyms:1-(2'-bromo-5'-hydroxybenzyl)-6,7-dimethoxy-5-hydroxy-3,4-dihydroisoquinoline hydrochloride

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Chemical Property of 1-(2'-bromo-5'-hydroxybenzyl)-6,7-dimethoxy-5-hydroxy-3,4-dihydroisoquinoline hydrochloride

Chemical Property:

Purity/Quality:

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Technology Process of 1-(2'-bromo-5'-hydroxybenzyl)-6,7-dimethoxy-5-hydroxy-3,4-dihydroisoquinoline hydrochloride

There total 6 articles about 1-(2'-bromo-5'-hydroxybenzyl)-6,7-dimethoxy-5-hydroxy-3,4-dihydroisoquinoline hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 121949-65-3
6-benzyloxy-1-(5'-benzyloxy-2'-bromobenzyl)-6,7-dimethoxy-3,4-dihydroisoquinoline hydrochloride

: 121949-70-0
1-(2'-bromo-5'-hydroxybenzyl)-6,7-dimethoxy-5-hydroxy-3,4-dihydroisoquinoline hydrochloride

Guidance literature:: With hydrogenchloride; In ethanol; for 1.5h; Yield given; Heating;
DOI:10.1002/jhet.5570250557

Reference yield:

: 19283-70-6
3,4-dimethoxysalicylaldehyde

: 121949-70-0
1-(2'-bromo-5'-hydroxybenzyl)-6,7-dimethoxy-5-hydroxy-3,4-dihydroisoquinoline hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: 90 percent / Na₂CO₃ / ethanol / 24 h / Heating

2: 92 percent / methylamine hydrochloride, anhydrous sodium acetate / Ambient temperature

3: 90 percent / lithium aluminium hydride / tetrahydrofuran / 2 h / Heating

4: 90 percent / 0.5 h / 140 - 150 °C

5: POCl₃ / CHCl₃ / 1.) room temp., 1 h; 2.) reflux, 2.5 h.

6: conc. hydrochloric acid / ethanol / 1.5 h / Heating

With hydrogenchloride; lithium aluminium tetrahydride; methylamine hydrochloride; sodium acetate; sodium carbonate; trichlorophosphate; In tetrahydrofuran; ethanol; chloroform;
DOI:10.1002/jhet.5570250557

Reference yield:

: 6527-13-5
3,4-dimethoxy-(phenylmethoxy)benzaldehyde

: 121949-70-0
1-(2'-bromo-5'-hydroxybenzyl)-6,7-dimethoxy-5-hydroxy-3,4-dihydroisoquinoline hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: 92 percent / methylamine hydrochloride, anhydrous sodium acetate / Ambient temperature

2: 90 percent / lithium aluminium hydride / tetrahydrofuran / 2 h / Heating

3: 90 percent / 0.5 h / 140 - 150 °C

4: POCl₃ / CHCl₃ / 1.) room temp., 1 h; 2.) reflux, 2.5 h.

5: conc. hydrochloric acid / ethanol / 1.5 h / Heating

With hydrogenchloride; lithium aluminium tetrahydride; methylamine hydrochloride; sodium acetate; trichlorophosphate; In tetrahydrofuran; ethanol; chloroform;
DOI:10.1002/jhet.5570250557