1-(2'-bromo-5'-hydroxybenzylidene)-2-carbethoxy-6,7-dimethoxy-5-hydroxy-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:1-(2'-bromo-5'-hydroxybenzylidene)-2-carbethoxy-6,7-dimethoxy-5-hydroxy-1,2,3,4-tetrahydroisoquinoline
CAS No.:121949-66-4
Molecular Formula:C₂₁H₂₂BrNO₆
Molecular Weight:464.313
Hs Code.:

Synonyms:1-(2'-bromo-5'-hydroxybenzylidene)-2-carbethoxy-6,7-dimethoxy-5-hydroxy-1,2,3,4-tetrahydroisoquinoline

Suppliers and Price of 1-(2'-bromo-5'-hydroxybenzylidene)-2-carbethoxy-6,7-dimethoxy-5-hydroxy-1,2,3,4-tetrahydroisoquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-(2'-bromo-5'-hydroxybenzylidene)-2-carbethoxy-6,7-dimethoxy-5-hydroxy-1,2,3,4-tetrahydroisoquinoline

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-(2'-bromo-5'-hydroxybenzylidene)-2-carbethoxy-6,7-dimethoxy-5-hydroxy-1,2,3,4-tetrahydroisoquinoline

There total 7 articles about 1-(2'-bromo-5'-hydroxybenzylidene)-2-carbethoxy-6,7-dimethoxy-5-hydroxy-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 541-41-3
chloroformic acid ethyl ester

: 121949-70-0
1-(2'-bromo-5'-hydroxybenzyl)-6,7-dimethoxy-5-hydroxy-3,4-dihydroisoquinoline hydrochloride

: 121949-66-4
1-(2'-bromo-5'-hydroxybenzylidene)-2-carbethoxy-6,7-dimethoxy-5-hydroxy-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With sodium carbonate; In chloroform; Ambient temperature;
DOI:10.1002/jhet.5570250557

Reference yield:

: 19283-70-6
3,4-dimethoxysalicylaldehyde

: 121949-66-4
1-(2'-bromo-5'-hydroxybenzylidene)-2-carbethoxy-6,7-dimethoxy-5-hydroxy-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 7 steps

1: 90 percent / Na₂CO₃ / ethanol / 24 h / Heating

2: 92 percent / methylamine hydrochloride, anhydrous sodium acetate / Ambient temperature

3: 90 percent / lithium aluminium hydride / tetrahydrofuran / 2 h / Heating

4: 90 percent / 0.5 h / 140 - 150 °C

5: POCl₃ / CHCl₃ / 1.) room temp., 1 h; 2.) reflux, 2.5 h.

6: conc. hydrochloric acid / ethanol / 1.5 h / Heating

7: 80 percent / 10percent aq. Na₂CO₃ / CHCl₃ / Ambient temperature

With hydrogenchloride; lithium aluminium tetrahydride; methylamine hydrochloride; sodium acetate; sodium carbonate; trichlorophosphate; In tetrahydrofuran; ethanol; chloroform;
DOI:10.1002/jhet.5570250557

Reference yield:

: 6527-13-5
3,4-dimethoxy-(phenylmethoxy)benzaldehyde

: 121949-66-4
1-(2'-bromo-5'-hydroxybenzylidene)-2-carbethoxy-6,7-dimethoxy-5-hydroxy-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 6 steps

1: 92 percent / methylamine hydrochloride, anhydrous sodium acetate / Ambient temperature

2: 90 percent / lithium aluminium hydride / tetrahydrofuran / 2 h / Heating

3: 90 percent / 0.5 h / 140 - 150 °C

4: POCl₃ / CHCl₃ / 1.) room temp., 1 h; 2.) reflux, 2.5 h.

5: conc. hydrochloric acid / ethanol / 1.5 h / Heating

6: 80 percent / 10percent aq. Na₂CO₃ / CHCl₃ / Ambient temperature

With hydrogenchloride; lithium aluminium tetrahydride; methylamine hydrochloride; sodium acetate; sodium carbonate; trichlorophosphate; In tetrahydrofuran; ethanol; chloroform;
DOI:10.1002/jhet.5570250557