methyl 1-methyl-6-({[2-(trifluoromethyl)phenyl]carbonyl}amino)-1H-benzimidazole-4-carboxylate

Base Information

Chemical Name:methyl 1-methyl-6-({[2-(trifluoromethyl)phenyl]carbonyl}amino)-1H-benzimidazole-4-carboxylate
CAS No.:1422206-13-0
Molecular Formula:C₁₈H₁₄F₃N₃O₃
Molecular Weight:377.323
Hs Code.:

Synonyms:methyl 1-methyl-6-({[2-(trifluoromethyl)phenyl]carbonyl}amino)-1H-benzimidazole-4-carboxylate

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Chemical Property of methyl 1-methyl-6-({[2-(trifluoromethyl)phenyl]carbonyl}amino)-1H-benzimidazole-4-carboxylate

Chemical Property:

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Technology Process of methyl 1-methyl-6-({[2-(trifluoromethyl)phenyl]carbonyl}amino)-1H-benzimidazole-4-carboxylate

There total 4 articles about methyl 1-methyl-6-({[2-(trifluoromethyl)phenyl]carbonyl}amino)-1H-benzimidazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1422205-94-4
methyl 6-({[2-(trifluoromethyl)phenyl]carbonyl}amino)-1H-benzimidazole-4-carboxylate

: 74-88-4
methyl iodide

: 1422206-13-0
methyl 1-methyl-6-({[2-(trifluoromethyl)phenyl]carbonyl}amino)-1H-benzimidazole-4-carboxylate

Guidance literature:: methyl 6-({[2-(trifluoromethyl)phenyl]carbonyl}amino)-1H-benzimidazole-4-carboxylate; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 1.5h; Cooling with ice;

methyl iodide; In tetrahydrofuran; at 20 ℃; Cooling with ice;

Reference yield:

: 1422205-93-3
methyl 6-amino-1H-benzimidazole-4-carboxylate

: 1422206-13-0
methyl 1-methyl-6-({[2-(trifluoromethyl)phenyl]carbonyl}amino)-1H-benzimidazole-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 3 h / Cooling with ice

2.1: sodium hydride / tetrahydrofuran / 1.5 h / 20 °C / Cooling with ice

2.2: 20 °C / Cooling with ice

With sodium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;

Reference yield:

: 37619-25-3
methyl 1H-benzo[d]imidazole-4-carboxylate

: 1422206-13-0
methyl 1-methyl-6-({[2-(trifluoromethyl)phenyl]carbonyl}amino)-1H-benzimidazole-4-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sulfuric acid; potassium nitrate / 4 h / 20 °C / Cooling with ice

2.1: 5%-palladium/activated carbon; hydrogen / methanol / 760.05 Torr

3.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 3 h / Cooling with ice

4.1: sodium hydride / tetrahydrofuran / 1.5 h / 20 °C / Cooling with ice

4.2: 20 °C / Cooling with ice

With sulfuric acid; 5%-palladium/activated carbon; hydrogen; sodium hydride; potassium nitrate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol;