1H-Benzimidazole-4-carboxylicacid,methylester(9CI)

Base Information

• Chemical Name: 1H-Benzimidazole-4-carboxylicacid,methylester(9CI)
• CAS No.: 37619-25-3
• Molecular Formula: C9H8 N2 O2
• Molecular Weight: 176.175
• Hs Code.: 2933990090
• Mol file: 37619-25-3.mol

Synonyms:1H-Benzimidazole-4-carboxylicacid, methyl ester (9CI); Methyl 3H-benzimidazole-4-carboxylate; Methyl4-benzimidazolecarboxylate

Chemical Property of 1H-Benzimidazole-4-carboxylicacid,methylester(9CI)

Chemical Property:

• Vapor Pressure: 3.9E-07mmHg at 25°C
• Refractive Index: 1.648
• Boiling Point: 416.2°Cat760mmHg
• PKA: 10.78±0.30(Predicted)
• Flash Point: 205.5°C
• PSA: 54.98000
• Density: 1.324g/cm³
• LogP: 1.34950
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

HPLC≥98% ^*data from raw suppliers

Methyl 1,3-benzodiazole-4-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Benzimidazole-4-carboxylicacid,methylester(9CI)

There total 14 articles about 1H-Benzimidazole-4-carboxylicacid,methylester(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

formic acid (64-18-6) + methyl 3-nitroanthranilate (57113-91-4) → methyl 3H-1,3-benzodiazole-4-carboxylate (37619-25-3)

Guidance literature:

With iron; ammonium chloride; In isopropyl alcohol; at 80 ℃; for 1h;

DOI:10.1055/s-0030-1259007

Reference yield: 92.0%

1-benzyl-1H-benzo[d]imidazole-7-carboxylic acid methyl ester → methyl 1H-benzo[d]imidazole-4-carboxylate (37619-25-3)

Guidance literature:

With triethylsilane; palladium 10% on activated carbon; In tetrahydrofuran; at 20 ℃; for 14h; Inert atmosphere;

DOI:10.1016/j.tetlet.2015.03.127

Reference yield: 89.0%

orthoformic acid triethyl ester (122-51-0) + 2,3-diaminobenzoic acid methyl ester (107582-20-7) → methyl 1H-benzo[d]imidazole-4-carboxylate (37619-25-3)

Guidance literature:

With toluene-4-sulfonic acid; Reflux;

DOI:10.1016/j.bmcl.2008.08.012

upstream raw materials:

orthoformic acid triethyl ester

formic acid

methyl 3-nitroanthranilate

methanol

Downstream raw materials:

1-phenyl-1H-benzoimidazole-4-carboxylic acid methyl ester

methyl 1-methyl-6-({[2-(trifluoromethyl)phenyl]carbonyl}amino)-1H-benzimidazole-4-carboxylate

methyl 6-amino-1H-benzimidazole-4-carboxylate

methyl 6-({[2-(trifluoromethyl)phenyl]carbonyl}amino)-1H-benzimidazole-4-carboxylate

Refernces

• 1、 -. "Benzimidazole derivative BI361 and preparation method and application thereof". Paragraph 0023-0025. . Retrieved 2021/02/20.
• 2、 -. "Benzimidazole derivative BI308 as well as preparation method and application thereof". Paragraph 0020-0022. . Retrieved 2021/06/09.