(4R,5S)-4-[((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-difluoro-methyl]-2,2-dimethyl-5-phenyl-[1,3]dioxolane

Base Information

Chemical Name:(4R,5S)-4-[((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-difluoro-methyl]-2,2-dimethyl-5-phenyl-[1,3]dioxolane
CAS No.:740839-76-3
Molecular Formula:C₁₇H₂₂F₂O₄
Molecular Weight:328.356
Hs Code.:

Synonyms:(4R,5S)-4-[((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-difluoro-methyl]-2,2-dimethyl-5-phenyl-[1,3]dioxolane

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Chemical Property of (4R,5S)-4-[((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-difluoro-methyl]-2,2-dimethyl-5-phenyl-[1,3]dioxolane

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Technology Process of (4R,5S)-4-[((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-difluoro-methyl]-2,2-dimethyl-5-phenyl-[1,3]dioxolane

There total 6 articles about (4R,5S)-4-[((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-difluoro-methyl]-2,2-dimethyl-5-phenyl-[1,3]dioxolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 67-64-1
acetone

: 740839-75-2
(1S,2R)-3-(2,2-Dimethyl-[1,3]dioxolan-4-yl)-3,3-difluoro-1-phenyl-propane-1,2-diol

: (4R,5S)-4-[((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-difluoro-methyl]-2,2-dimethyl-5-phenyl-[1,3]dioxolane

: 740839-76-3
(4R,5S)-4-[((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-difluoro-methyl]-2,2-dimethyl-5-phenyl-[1,3]dioxolane

Guidance literature:: With toluene-4-sulfonic acid; copper(II) sulfate;
DOI:10.1039/b405067c

Reference yield:

: 82477-43-8
bromodifluoromethylphenylacetylene

: 740839-76-3
(4R,5S)-4-[((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-difluoro-methyl]-2,2-dimethyl-5-phenyl-[1,3]dioxolane

Guidance literature:: Multi-step reaction with 5 steps

1: 69 percent / NaI; Zn; Hg(OAc)2 / tetrahydrofuran / 18 h / 20 °C

2: Red-Al / toluene / 20 °C

3: TsOH; CuSO₄

4: MeSO2NH2; AD mix-β

5: 43 percent / TsOH; CuSO₄

With methanesulfonamide; mercury(II) diacetate; toluene-4-sulfonic acid; copper(II) sulfate; 1,4-bis(9-O-dihydroquinidine)phthalazine; sodium bis(2-methoxyethoxy)aluminium dihydride; sodium iodide; zinc; In tetrahydrofuran; toluene; 4: Sharpless asymmetric dihydroxylation;
DOI:10.1039/b405067c

Reference yield:

: 536-74-3
phenylacetylene

: 740839-76-3
(4R,5S)-4-[((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-difluoro-methyl]-2,2-dimethyl-5-phenyl-[1,3]dioxolane

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-BuLi / tetrahydrofuran; hexane / 0.25 h / 0 °C

1.2: tetrahydrofuran; hexane / 2 h / -78 - 0 °C

2.1: 69 percent / NaI; Zn; Hg(OAc)2 / tetrahydrofuran / 18 h / 20 °C

3.1: Red-Al / toluene / 20 °C

4.1: TsOH; CuSO₄

5.1: MeSO2NH2; AD mix-β

6.1: 43 percent / TsOH; CuSO₄

With n-butyllithium; methanesulfonamide; mercury(II) diacetate; toluene-4-sulfonic acid; copper(II) sulfate; 1,4-bis(9-O-dihydroquinidine)phthalazine; sodium bis(2-methoxyethoxy)aluminium dihydride; sodium iodide; zinc; In tetrahydrofuran; hexane; toluene; 5.1: Sharpless asymmetric dihydroxylation;
DOI:10.1039/b405067c