(8S,9S,11S,13S,14S,17S)-17-Benzyloxy-13-ethyl-3-methoxy-11-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-11-ol

Base Information

Chemical Name:(8S,9S,11S,13S,14S,17S)-17-Benzyloxy-13-ethyl-3-methoxy-11-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-11-ol
CAS No.:190507-48-3
Molecular Formula:C₂₈H₃₆O₃
Molecular Weight:420.592
Hs Code.:

Synonyms:(8S,9S,11S,13S,14S,17S)-17-Benzyloxy-13-ethyl-3-methoxy-11-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-11-ol

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Chemical Property of (8S,9S,11S,13S,14S,17S)-17-Benzyloxy-13-ethyl-3-methoxy-11-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-11-ol

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Technology Process of (8S,9S,11S,13S,14S,17S)-17-Benzyloxy-13-ethyl-3-methoxy-11-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-11-ol

There total 2 articles about (8S,9S,11S,13S,14S,17S)-17-Benzyloxy-13-ethyl-3-methoxy-11-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-11-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 917-54-4
methyllithium

: 97996-45-7
17β-benzyloxy-D-13β-ethyl-3-methoxy-estra-1,3,5(10)-triene-11-one

: 190507-48-3
(8S,9S,11S,13S,14S,17S)-17-Benzyloxy-13-ethyl-3-methoxy-11-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-11-ol

Guidance literature:: In diethyl ether; benzene; at 10 - 15 ℃; for 3h;
DOI:10.1016/S0039-128X(97)00006-8

Reference yield:

: 87834-70-6
17β-benzyloxy-D-13β-ethyl-11α-hydroxy-3-methoxy-estra-1,3,5(10)-triene

: 190507-48-3
(8S,9S,11S,13S,14S,17S)-17-Benzyloxy-13-ethyl-3-methoxy-11-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-11-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 64 percent / pyridinium chlorochromate / CH₂Cl₂ / 3 h / Ambient temperature

2: 98 percent / benzene; diethyl ether / 3 h / 10 - 15 °C

With pyridinium chlorochromate; In diethyl ether; dichloromethane; benzene;
DOI:10.1016/S0039-128X(97)00006-8

Reference yield:

: 190507-48-3
(8S,9S,11S,13S,14S,17S)-17-Benzyloxy-13-ethyl-3-methoxy-11-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-11-ol

: 54024-17-8
13β-ethyl-11-methylenegon-4-en-3,17-dione

Guidance literature:: Multi-step reaction with 4 steps

1: 76 percent / Li, liq. NH₃, t-BuOH / tetrahydrofuran / 0.5 h / -55 - -50 °C

2: 92 percent / aq. HCl / acetone / 1 h / 25 °C

3: 91 percent / CrO₃, H₂SO₄ / acetone / 0.17 h / 0 - 5 °C

4: 80.3 percent / TsOH*H₂O, formic acid / 7 h / 50 - 60 °C

With chromium(VI) oxide; hydrogenchloride; formic acid; sulfuric acid; ammonia; lithium; toluene-4-sulfonic acid; tert-butyl alcohol; In tetrahydrofuran; acetone;
DOI:10.1016/S0039-128X(97)00006-8