87834-70-6

Upstream product

• 87834-69-3 17β-benzyloxy-D-13β-ethyl-3-methoxy-estra-1,3,5(10),9(11)-tetraene 
• 100-39-0 benzyl bromide 
• 7443-72-3 18-methyl-3-methoxy-1,3,5(10),8-estratetraen-17β-ol 

Downstream Products

• 97996-45-7 17β-benzyloxy-D-13β-ethyl-3-methoxy-estra-1,3,5(10)-triene-11-one 
• 190507-48-3 (8S,9S,11S,13S,14S,17S)-17-Benzyloxy-13-ethyl-3-methoxy-11-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-11-ol 
• 54024-17-8 13β-ethyl-11-methylenegon-4-en-3,17-dione 

Relevant academic research and scientific papers

Synthesis method of desogestrel drug intermediate

The invention discloses a synthesis method of a desogestrel drug intermediate. The synthesis method comprises the following steps: taking a compound I as a raw material, and protecting by 17-site hydroxyl to obtain a compound II; reflowing the compound II in an acidic mixed solvent to obtain a compound III; taking the compound III to be subjected to a hydroxylation reaction, so as to obtain a compound IV; oxidizing the compound IV by an oxide to obtain the desogestrel drug intermediate V. The preparation method disclosed by the invention is simple and has moderate reaction conditions, and the yield is relatively high.