97996-45-7Relevant academic research and scientific papers
Synthesis of 13-ethyl-17-hydroxy-11-methylene-18,19-dinor-17α-pregn-4- en-20-yn-3-one (3-oxo desogestrel)
Gao, Hongwu,Su, Xiangdong,Li, Zhensu
, p. 398 - 402 (1997)
A synthesis of the steroid hormone, 3-keto-desogestrel (1), with the total yield of 10% starting from d-13β-ethyl-3-methoxy-gona-1,3,5(10),8- tetraen-18β-ol (3) is described.
Synthesis method of desogestrel drug intermediate
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Paragraph 0027; 0028; 0029, (2016/10/20)
The invention discloses a synthesis method of a desogestrel drug intermediate. The synthesis method comprises the following steps: taking a compound I as a raw material, and protecting by 17-site hydroxyl to obtain a compound II; reflowing the compound II in an acidic mixed solvent to obtain a compound III; taking the compound III to be subjected to a hydroxylation reaction, so as to obtain a compound IV; oxidizing the compound IV by an oxide to obtain the desogestrel drug intermediate V. The preparation method disclosed by the invention is simple and has moderate reaction conditions, and the yield is relatively high.
An Anomalous Oxidation of 11α-Hydroxyoestratrienes with Pyridinium Dichromate.
Hanson, James R.,Hitchcock, Peter B.,Yang-zhi, Ling,Jia-yi, Tan
, p. 651 - 670 (2007/10/02)
The oxidation of 3,17β-dibenzyloxy-11α-hydroxyoestra-1,3,5(10)-triene with pyridinium dichromate has been shown to yield the corresponding 9α-hydroxy-11-ketone as well as the anticipated 11-ketone.The 9β-methyl ether was obtained as a result of a methanolic work-up and is shown to arise by an acid-catalysed methanolysis of the 9α-alcohol.The stereochemistry of the 9β-methyl ether was confirmed by X-ray crystallographic analysis.
