6-benzyloxy-1,2,3,4-tetrahydro-isoquinoline-1-carboxylic acid (2-diisopropylamino-ethyl)-amide

Base Information

Chemical Name:6-benzyloxy-1,2,3,4-tetrahydro-isoquinoline-1-carboxylic acid (2-diisopropylamino-ethyl)-amide
CAS No.:373638-29-0
Molecular Formula:C₂₅H₃₅N₃O₂
Molecular Weight:409.572
Hs Code.:

Synonyms:6-benzyloxy-1,2,3,4-tetrahydro-isoquinoline-1-carboxylic acid (2-diisopropylamino-ethyl)-amide

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Chemical Property of 6-benzyloxy-1,2,3,4-tetrahydro-isoquinoline-1-carboxylic acid (2-diisopropylamino-ethyl)-amide

Chemical Property:

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Technology Process of 6-benzyloxy-1,2,3,4-tetrahydro-isoquinoline-1-carboxylic acid (2-diisopropylamino-ethyl)-amide

There total 10 articles about 6-benzyloxy-1,2,3,4-tetrahydro-isoquinoline-1-carboxylic acid (2-diisopropylamino-ethyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 373633-77-3
1-[[[2-[Bis(1-methylethyl)amino]ethyl]amino]carbonyl]-3,4-dihydro-6-(phenylmethoxy)-2(1H)-isoquinoline-carboxylic acid,1,1-dimethylethyl ester

: 373638-29-0
6-benzyloxy-1,2,3,4-tetrahydro-isoquinoline-1-carboxylic acid (2-diisopropylamino-ethyl)-amide

Guidance literature:: 1-[[[2-[Bis(1-methylethyl)amino]ethyl]amino]carbonyl]-3,4-dihydro-6-(phenylmethoxy)-2(1H)-isoquinoline-carboxylic acid,1,1-dimethylethyl ester; With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 1h;

With sodium hydroxide; In water; ethyl acetate; pH=~ 8;

Reference yield:

: 588-05-6
m-tyramine

: 373638-29-0
6-benzyloxy-1,2,3,4-tetrahydro-isoquinoline-1-carboxylic acid (2-diisopropylamino-ethyl)-amide

Guidance literature:: Multi-step reaction with 7 steps

1: aq. HCl

2: TMSiCl

3: Et₃N

4: NaH

5: NaOH

6: EDAC; HOAT

7: HCl / dioxane; methanol

With hydrogenchloride; sodium hydroxide; chloro-trimethyl-silane; 1-hydroxy-7-aza-benzotriazole; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,4-dioxane; methanol;
DOI:10.1016/j.bmcl.2005.02.040

Reference yield:

: 91523-50-1
rac-6-hydroxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid

: 373638-29-0
6-benzyloxy-1,2,3,4-tetrahydro-isoquinoline-1-carboxylic acid (2-diisopropylamino-ethyl)-amide

Guidance literature:: Multi-step reaction with 6 steps

1: TMSiCl

2: Et₃N

3: NaH

4: NaOH

5: EDAC; HOAT

6: HCl / dioxane; methanol

With hydrogenchloride; sodium hydroxide; chloro-trimethyl-silane; 1-hydroxy-7-aza-benzotriazole; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,4-dioxane; methanol;
DOI:10.1016/j.bmcl.2005.02.040