1-[[[2-[Bis(1-methylethyl)amino]ethyl]amino]carbonyl]-3,4-dihydro-6-(phenylmethoxy)-2(1H)-isoquinoline-carboxylic acid,1,1-dimethylethyl ester

Base Information

Chemical Name:1-[[[2-[Bis(1-methylethyl)amino]ethyl]amino]carbonyl]-3,4-dihydro-6-(phenylmethoxy)-2(1H)-isoquinoline-carboxylic acid,1,1-dimethylethyl ester
CAS No.:373633-77-3
Molecular Formula:C₃₀H₄₃N₃O₄
Molecular Weight:509.689
Hs Code.:

Synonyms:1-[[[2-[Bis(1-methylethyl)amino]ethyl]amino]carbonyl]-3,4-dihydro-6-(phenylmethoxy)-2(1H)-isoquinoline-carboxylic acid,1,1-dimethylethyl ester

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Chemical Property of 1-[[[2-[Bis(1-methylethyl)amino]ethyl]amino]carbonyl]-3,4-dihydro-6-(phenylmethoxy)-2(1H)-isoquinoline-carboxylic acid,1,1-dimethylethyl ester

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Technology Process of 1-[[[2-[Bis(1-methylethyl)amino]ethyl]amino]carbonyl]-3,4-dihydro-6-(phenylmethoxy)-2(1H)-isoquinoline-carboxylic acid,1,1-dimethylethyl ester

There total 10 articles about 1-[[[2-[Bis(1-methylethyl)amino]ethyl]amino]carbonyl]-3,4-dihydro-6-(phenylmethoxy)-2(1H)-isoquinoline-carboxylic acid,1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 121-05-1
N',N'-diisopropyl-ethane-1,2-diamine

: 373638-25-6
6-benzyloxy-3,4-dihydro-1H-isoquinoline-1,2-dicarboxylic acid 2-tert-butyl ester

: 373633-77-3
1-[[[2-[Bis(1-methylethyl)amino]ethyl]amino]carbonyl]-3,4-dihydro-6-(phenylmethoxy)-2(1H)-isoquinoline-carboxylic acid,1,1-dimethylethyl ester

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In DMF (N,N-dimethyl-formamide); at 20 ℃;

Reference yield: 79.0%

: 373633-77-3
1-[[[2-[Bis(1-methylethyl)amino]ethyl]amino]carbonyl]-3,4-dihydro-6-(phenylmethoxy)-2(1H)-isoquinoline-carboxylic acid,1,1-dimethylethyl ester

Guidance literature:

Reference yield:

: 588-05-6
m-tyramine

: 373633-77-3
1-[[[2-[Bis(1-methylethyl)amino]ethyl]amino]carbonyl]-3,4-dihydro-6-(phenylmethoxy)-2(1H)-isoquinoline-carboxylic acid,1,1-dimethylethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: aq. HCl

2: TMSiCl

3: Et₃N

4: NaH

5: NaOH

6: EDAC; HOAT

With hydrogenchloride; sodium hydroxide; chloro-trimethyl-silane; 1-hydroxy-7-aza-benzotriazole; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
DOI:10.1016/j.bmcl.2005.02.040