2-amino-N-{3-(2-chlorobenzoyl)-5-[2-(4-isobutylphenyl)ethyl]-2-thienyl}acetamide

Base Information

Chemical Name:2-amino-N-{3-(2-chlorobenzoyl)-5-[2-(4-isobutylphenyl)ethyl]-2-thienyl}acetamide
CAS No.:117280-07-6
Molecular Formula:C₂₅H₂₇ClN₂O₂S
Molecular Weight:455.021
Hs Code.:

Synonyms:2-amino-N-{3-(2-chlorobenzoyl)-5-[2-(4-isobutylphenyl)ethyl]-2-thienyl}acetamide

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Chemical Property of 2-amino-N-{3-(2-chlorobenzoyl)-5-[2-(4-isobutylphenyl)ethyl]-2-thienyl}acetamide

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Technology Process of 2-amino-N-{3-(2-chlorobenzoyl)-5-[2-(4-isobutylphenyl)ethyl]-2-thienyl}acetamide

There total 8 articles about 2-amino-N-{3-(2-chlorobenzoyl)-5-[2-(4-isobutylphenyl)ethyl]-2-thienyl}acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1027498-92-5
N-{3-(2-Chloro-benzoyl)-5-[2-(4-isobutyl-phenyl)-ethyl]-thiophen-2-yl}-2-iodo-acetamide

: 117280-07-6
2-amino-N-{3-(2-chlorobenzoyl)-5-[2-(4-isobutylphenyl)ethyl]-2-thienyl}acetamide

Guidance literature:: With ammonia; In tetrahydrofuran; at -30 - 20 ℃; for 4h;
DOI:10.1016/0223-5234(96)85877-6

Reference yield:

: 538-93-2
1-phenyl-2-methylpropane

: 117280-07-6
2-amino-N-{3-(2-chlorobenzoyl)-5-[2-(4-isobutylphenyl)ethyl]-2-thienyl}acetamide

Guidance literature:: Multi-step reaction with 8 steps

1: 93 percent / AlCl₃ / 1,2-dichloro-ethane / 4 h

2: 89 percent / hydrazine hydrate, potassium hydroxide / ethane-1,2-diol / 20 - 160 °C

3: NaBH₄, BF₃*OEt₂

4: 97 percent / CrO₃, celite, pyridine / CH₂Cl₂ / 1.5 h / Ambient temperature

5: 70 percent / triethylamine, sulfur / dimethylformamide / 4 h / 50 - 60 °C

6: 93 percent / CHCl₃ / 2 h / Heating

7: sodium iodide / tetrahydrofuran / 2 h / Heating

8: liquid ammonia / tetrahydrofuran / 4 h / -30 - 20 °C

With pyridine; chromium(VI) oxide; potassium hydroxide; sodium tetrahydroborate; aluminium trichloride; Celite; boron trifluoride diethyl etherate; ammonia; sulfur; hydrazine hydrate; triethylamine; sodium iodide; In tetrahydrofuran; dichloromethane; chloroform; ethylene glycol; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/0223-5234(96)85877-6

Reference yield:

: 73120-67-9
4-(4-isobutylphenyl)-4-oxobutanoic acid

: 117280-07-6
2-amino-N-{3-(2-chlorobenzoyl)-5-[2-(4-isobutylphenyl)ethyl]-2-thienyl}acetamide

Guidance literature:: Multi-step reaction with 7 steps

1: 89 percent / hydrazine hydrate, potassium hydroxide / ethane-1,2-diol / 20 - 160 °C

2: NaBH₄, BF₃*OEt₂

3: 97 percent / CrO₃, celite, pyridine / CH₂Cl₂ / 1.5 h / Ambient temperature

4: 70 percent / triethylamine, sulfur / dimethylformamide / 4 h / 50 - 60 °C

5: 93 percent / CHCl₃ / 2 h / Heating

6: sodium iodide / tetrahydrofuran / 2 h / Heating

7: liquid ammonia / tetrahydrofuran / 4 h / -30 - 20 °C

With pyridine; chromium(VI) oxide; potassium hydroxide; sodium tetrahydroborate; Celite; boron trifluoride diethyl etherate; ammonia; sulfur; hydrazine hydrate; triethylamine; sodium iodide; In tetrahydrofuran; dichloromethane; chloroform; ethylene glycol; N,N-dimethyl-formamide;
DOI:10.1016/0223-5234(96)85877-6