2,2,2-trichloro-N-{3-[3-(3,5-difluorophenyl)-6-oxo-6H-pyridazin-1-ylmethyl]-phenyl}acetamide

Base Information

Chemical Name:2,2,2-trichloro-N-{3-[3-(3,5-difluorophenyl)-6-oxo-6H-pyridazin-1-ylmethyl]-phenyl}acetamide
CAS No.:1119204-86-2
Molecular Formula:C₁₉H₁₂Cl₃F₂N₃O₂
Molecular Weight:458.679
Hs Code.:

Synonyms:2,2,2-trichloro-N-{3-[3-(3,5-difluorophenyl)-6-oxo-6H-pyridazin-1-ylmethyl]-phenyl}acetamide

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Chemical Property of 2,2,2-trichloro-N-{3-[3-(3,5-difluorophenyl)-6-oxo-6H-pyridazin-1-ylmethyl]-phenyl}acetamide

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Technology Process of 2,2,2-trichloro-N-{3-[3-(3,5-difluorophenyl)-6-oxo-6H-pyridazin-1-ylmethyl]-phenyl}acetamide

There total 6 articles about 2,2,2-trichloro-N-{3-[3-(3,5-difluorophenyl)-6-oxo-6H-pyridazin-1-ylmethyl]-phenyl}acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1007098-98-7
2-(3-aminobenzyl)-6-(3,5-difluorophenyl)-2H-pyridazin-3-one

: 76-02-8
trifluoroacetyl chloride

: 1119204-86-2
2,2,2-trichloro-N-{3-[3-(3,5-difluorophenyl)-6-oxo-6H-pyridazin-1-ylmethyl]-phenyl}acetamide

Guidance literature:: With pyridine; In dichloromethane; at 0 - 20 ℃; for 18h;

Reference yield:

: 156545-07-2
3,5-difluorophenylboronic acid

: 1119204-86-2
2,2,2-trichloro-N-{3-[3-(3,5-difluorophenyl)-6-oxo-6H-pyridazin-1-ylmethyl]-phenyl}acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water / 5 h / 100 °C

2: water; formic acid / 18 h / Heating

3: potassium carbonate / 1-methyl-pyrrolidin-2-one / 6 h / 40 - 70 °C

4: hydrogen / palladium on carbon / tetrahydrofuran / 20 °C / 760.05 Torr

5: pyridine / dichloromethane / 18 h / 0 - 20 °C

With pyridine; formic acid; water; hydrogen; sodium carbonate; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on carbon; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane; water;

Reference yield:

: 1007098-93-2
6-(3,5-difluorophenyl)pyridazine-3(2H)-one

: 1119204-86-2
2,2,2-trichloro-N-{3-[3-(3,5-difluorophenyl)-6-oxo-6H-pyridazin-1-ylmethyl]-phenyl}acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 6 h / 40 - 70 °C

2: hydrogen / palladium on carbon / tetrahydrofuran / 20 °C / 760.05 Torr

3: pyridine / dichloromethane / 18 h / 0 - 20 °C

With pyridine; hydrogen; potassium carbonate; palladium on carbon; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane;