tert-butyl 4-(6-chloro-1-oxo-1,2,3,4-tetrahydronaphthalene-2-carbonyl)piperidine-1-carboxylate

Base Information

• Chemical Name: tert-butyl 4-(6-chloro-1-oxo-1,2,3,4-tetrahydronaphthalene-2-carbonyl)piperidine-1-carboxylate
• CAS No.: 1463609-22-4
• Molecular Formula: C₂₁H₂₆ClNO₄
• Molecular Weight: 391.895
• Mol file: 1463609-22-4.mol

Synonyms:tert-butyl 4-(6-chloro-1-oxo-1,2,3,4-tetrahydronaphthalene-2-carbonyl)piperidine-1-carboxylate

Chemical Property of tert-butyl 4-(6-chloro-1-oxo-1,2,3,4-tetrahydronaphthalene-2-carbonyl)piperidine-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 4-(6-chloro-1-oxo-1,2,3,4-tetrahydronaphthalene-2-carbonyl)piperidine-1-carboxylate

There total 1 articles about tert-butyl 4-(6-chloro-1-oxo-1,2,3,4-tetrahydronaphthalene-2-carbonyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

6-chloro-3,4-dihydronaphthalen-1(2H)-one (26673-31-4) + N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid (84358-13-4,174286-31-8) → tert-butyl 4-(6-chloro-1-oxo-1,2,3,4-tetrahydronaphthalene-2-carbonyl)piperidine-1-carboxylate (1463609-22-4)

Guidance literature:

N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid; With 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide; at 20 ℃; for 0.75h;

6-chloro-3,4-dihydronaphthalen-1(2H)-one; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 120 ℃; for 6h;

DOI:10.3390/molecules18078147

Reference yield:

tert-butyl 4-(6-chloro-1-oxo-1,2,3,4-tetrahydronaphthalene-2-carbonyl)piperidine-1-carboxylate (1463609-22-4) → 3-(1-benzylpiperidin-4-yl)-7-chloro-4,5-dihydro-1H-benzo[g]indazole (1463609-31-5)

Guidance literature:

Multi-step reaction with 3 steps

1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 20 °C

3: hydrazine hydrate / methanol / 12 h / 20 °C

With hydrazine hydrate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.3390/molecules18078147

Reference yield:

tert-butyl 4-(6-chloro-1-oxo-1,2,3,4-tetrahydronaphthalene-2-carbonyl)piperidine-1-carboxylate (1463609-22-4) → 2-(1-benzylpiperidine-4-carbonyl)-6-chloro-3,4-dihydronaphthalen-1(2H)-one (1463609-27-9)

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 20 °C

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.3390/molecules18078147

upstream raw materials:

6-chloro-3,4-dihydronaphthalen-1(2H)-one

N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid

Downstream raw materials:

3-(1-benzylpiperidin-4-yl)-7-chloro-4,5-dihydro-1H-benzo[g]indazole

1H-1-oxa-2-aza-7-chloro-3-(1-phenethylpiperidin-4-yl)-4,5-dihydronaphto[2,1-d]isoxazole

2H-1-aza-2-oxa-7-chloro-3-(1-phenethylpiperidin-4-yl)-4,5-dihydronaphto[1,2-c]isoxazole

2-(1-benzylpiperidine-4-carbonyl)-6-chloro-3,4-dihydronaphthalen-1(2H)-one