1H-1-oxa-2-aza-7-chloro-3-(1-phenethylpiperidin-4-yl)-4,5-dihydronaphto[2,1-d]isoxazole

Base Information

Chemical Name:1H-1-oxa-2-aza-7-chloro-3-(1-phenethylpiperidin-4-yl)-4,5-dihydronaphto[2,1-d]isoxazole
CAS No.:1463609-33-7
Molecular Formula:C₂₄H₂₅ClN₂O
Molecular Weight:392.928
Hs Code.:

Synonyms:1H-1-oxa-2-aza-7-chloro-3-(1-phenethylpiperidin-4-yl)-4,5-dihydronaphto[2,1-d]isoxazole

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Chemical Property of 1H-1-oxa-2-aza-7-chloro-3-(1-phenethylpiperidin-4-yl)-4,5-dihydronaphto[2,1-d]isoxazole

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Technology Process of 1H-1-oxa-2-aza-7-chloro-3-(1-phenethylpiperidin-4-yl)-4,5-dihydronaphto[2,1-d]isoxazole

There total 5 articles about 1H-1-oxa-2-aza-7-chloro-3-(1-phenethylpiperidin-4-yl)-4,5-dihydronaphto[2,1-d]isoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 1463609-29-1
6-chloro-2-(1-phenethylpiperidine-4-carbonyl)-3,4-dihydronaphthalen-1(2H)-one

: 1463609-33-7
1H-1-oxa-2-aza-7-chloro-3-(1-phenethylpiperidin-4-yl)-4,5-dihydronaphto[2,1-d]isoxazole

: 1463609-35-9
2H-1-aza-2-oxa-7-chloro-3-(1-phenethylpiperidin-4-yl)-4,5-dihydronaphto[1,2-c]isoxazole

Guidance literature:: With hydroxylamine hydrochloride; acetic acid; In ethanol; at 80 ℃; for 24h;
DOI:10.3390/molecules18078147

Reference yield:

: 1463609-22-4
tert-butyl 4-(6-chloro-1-oxo-1,2,3,4-tetrahydronaphthalene-2-carbonyl)piperidine-1-carboxylate

: 1463609-33-7
1H-1-oxa-2-aza-7-chloro-3-(1-phenethylpiperidin-4-yl)-4,5-dihydronaphto[2,1-d]isoxazole

: 1463609-35-9
2H-1-aza-2-oxa-7-chloro-3-(1-phenethylpiperidin-4-yl)-4,5-dihydronaphto[1,2-c]isoxazole

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 60 °C

3: hydroxylamine hydrochloride; acetic acid / ethanol / 24 h / 80 °C

With hydroxylamine hydrochloride; acetic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.3390/molecules18078147

Reference yield:

: 26673-31-4
6-chloro-3,4-dihydronaphthalen-1(2H)-one

: 1463609-33-7
1H-1-oxa-2-aza-7-chloro-3-(1-phenethylpiperidin-4-yl)-4,5-dihydronaphto[2,1-d]isoxazole

: 1463609-35-9
2H-1-aza-2-oxa-7-chloro-3-(1-phenethylpiperidin-4-yl)-4,5-dihydronaphto[1,2-c]isoxazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 0.75 h / 20 °C

1.2: 6 h / 120 °C

2.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 60 °C

4.1: hydroxylamine hydrochloride; acetic acid / ethanol / 24 h / 80 °C

With hydroxylamine hydrochloride; acetic acid; N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole; trifluoroacetic acid; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.3390/molecules18078147