2-chloro-1-[4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidin-1-yl]-ethanone

Base Information

Chemical Name:2-chloro-1-[4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidin-1-yl]-ethanone
CAS No.:1402049-22-2
Molecular Formula:C₃₆H₅₄ClNO₃S₂
Molecular Weight:648.415
Hs Code.:

Synonyms:2-chloro-1-[4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidin-1-yl]-ethanone

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Chemical Property of 2-chloro-1-[4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidin-1-yl]-ethanone

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Technology Process of 2-chloro-1-[4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidin-1-yl]-ethanone

There total 4 articles about 2-chloro-1-[4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidin-1-yl]-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1402048-10-5
2,6-di-tert-butyl-4-[4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidin-4-ylsulfanyl]-phenol

: 79-04-9
chloroacetyl chloride

: 1402049-22-2
2-chloro-1-[4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidin-1-yl]-ethanone

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; for 0.166667h;

Reference yield:

: 29976-53-2
N-ethoxycarbonyl-4-piperidone

: 1402049-22-2
2-chloro-1-[4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidin-1-yl]-ethanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / methanol / 20 h / 45 °C

2.1: potassium tert-butylate / tetrahydrofuran / 5 h / Inert atmosphere; Reflux

3.1: isopropyl alcohol; potassium hydroxide / 18 h / Inert atmosphere; Reflux

3.2: 20 °C / pH ~ 6

4.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.17 h

With hydrogenchloride; potassium tert-butylate; N-ethyl-N,N-diisopropylamine; isopropyl alcohol; potassium hydroxide; In tetrahydrofuran; methanol;

Reference yield:

: 1402048-09-2
4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidine-1-carboxylic acid ethyl ester

: 1402049-22-2
2-chloro-1-[4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidin-1-yl]-ethanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: isopropyl alcohol; potassium hydroxide / 18 h / Inert atmosphere; Reflux

1.2: 20 °C / pH ~ 6

2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.17 h

With N-ethyl-N,N-diisopropylamine; isopropyl alcohol; potassium hydroxide; In tetrahydrofuran;