5-(12-fluoro-6,7-dihydro-5H-pyrido[2‘,3‘:3,4]azepino[1,2-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

Base Information

Chemical Name:5-(12-fluoro-6,7-dihydro-5H-pyrido[2‘,3‘:3,4]azepino[1,2-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide
CAS No.:1621704-74-2
Molecular Formula:C₃₄H₂₈F₂N₄O₄S
Molecular Weight:626.684
Hs Code.:

5-(12-fluoro-6,7-dihydro-5H-pyrido[2‘,3‘:3,4]azepino[1,2-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

Synonyms:5-(12-fluoro-6,7-dihydro-5H-pyrido[2‘,3‘:3,4]azepino[1,2-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

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Chemical Property of 5-(12-fluoro-6,7-dihydro-5H-pyrido[2‘,3‘:3,4]azepino[1,2-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

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Technology Process of 5-(12-fluoro-6,7-dihydro-5H-pyrido[2‘,3‘:3,4]azepino[1,2-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

There total 8 articles about 5-(12-fluoro-6,7-dihydro-5H-pyrido[2‘,3‘:3,4]azepino[1,2-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1621706-05-5
5-(6-(4-fluoro-1H-indol-2-yl)-5-(3-hydroxypropyl)pyridin-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

: 1621704-74-2
5-(12-fluoro-6,7-dihydro-5H-pyrido[2‘,3‘:3,4]azepino[1,2-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 20 ℃; for 10h;

Reference yield:

: 1621706-02-2
(E)-ethyl 3-(2, 6-dichloropyridin-3-yl)acrylate

: 1621704-74-2
5-(12-fluoro-6,7-dihydro-5H-pyrido[2‘,3‘:3,4]azepino[1,2-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: palladium 10% on activated carbon; hydrogen / ethanol / 1 h / 760.05 Torr

2: lithium borohydride / tetrahydrofuran / 2.5 h / 20 °C

3: caesium carbonate; XPhos / water; 1,4-dioxane / 4 h / 70 °C / Inert atmosphere

4: caesium carbonate; 1,1'-bis(di-tert-butylphosphino)ferrocene-dichloropalladium(II) / water; 1,4-dioxane / 3 h / 90 °C / Inert atmosphere

5: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 10 h / 20 °C

With lithium borohydride; di-isopropyl azodicarboxylate; palladium 10% on activated carbon; 1,1'-bis(di-tert-butylphosphino)ferrocene-dichloropalladium(II); hydrogen; caesium carbonate; triphenylphosphine; XPhos; In tetrahydrofuran; 1,4-dioxane; ethanol; water;

Reference yield:

: 148493-37-2
2,6-dichloro-3-iodo-pyridine

: 1621704-74-2
5-(12-fluoro-6,7-dihydro-5H-pyrido[2‘,3‘:3,4]azepino[1,2-a]indol-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: 1,1'-bis(di-tert-butylphosphino)ferrocene-dichloropalladium(II); potassium carbonate / tetrahydrofuran; water / 2 h / 20 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / ethanol / 1 h / 760.05 Torr

3: lithium borohydride / tetrahydrofuran / 2.5 h / 20 °C

4: caesium carbonate; XPhos / water; 1,4-dioxane / 4 h / 70 °C / Inert atmosphere

5: caesium carbonate; 1,1'-bis(di-tert-butylphosphino)ferrocene-dichloropalladium(II) / water; 1,4-dioxane / 3 h / 90 °C / Inert atmosphere

6: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 10 h / 20 °C

With lithium borohydride; di-isopropyl azodicarboxylate; palladium 10% on activated carbon; 1,1'-bis(di-tert-butylphosphino)ferrocene-dichloropalladium(II); hydrogen; potassium carbonate; caesium carbonate; triphenylphosphine; XPhos; In tetrahydrofuran; 1,4-dioxane; ethanol; water;