5-(6-chloro-5-(3-hydroxypropyl)pyridin-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

Base Information

Chemical Name:5-(6-chloro-5-(3-hydroxypropyl)pyridin-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide
CAS No.:1621706-04-4
Molecular Formula:C₂₆H₂₅ClFN₃O₅S
Molecular Weight:546.019
Hs Code.:

Synonyms:5-(6-chloro-5-(3-hydroxypropyl)pyridin-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

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Chemical Property of 5-(6-chloro-5-(3-hydroxypropyl)pyridin-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

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Technology Process of 5-(6-chloro-5-(3-hydroxypropyl)pyridin-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

There total 5 articles about 5-(6-chloro-5-(3-hydroxypropyl)pyridin-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1333340-17-2
2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzofuran-3-carboxamide

: ethyl 3-(2,6-dichloropyridin-3-yl)propanoate

: 1621706-04-4
5-(6-chloro-5-(3-hydroxypropyl)pyridin-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

Guidance literature:: With caesium carbonate; XPhos; In 1,4-dioxane; water; at 70 ℃; for 4h; Inert atmosphere;

Reference yield:

: 1333340-17-2
2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzofuran-3-carboxamide

: C₁₀H₁₃Cl₂NO

: 1621706-04-4
5-(6-chloro-5-(3-hydroxypropyl)pyridin-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

Guidance literature:: With caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; In 1,4-dioxane; water; at 70 ℃; for 4.08333h; Inert atmosphere;

Reference yield:

: 148493-37-2
2,6-dichloro-3-iodo-pyridine

: 1621706-04-4
5-(6-chloro-5-(3-hydroxypropyl)pyridin-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: 1,1'-bis(di-tert-butylphosphino)ferrocene-dichloropalladium(II); potassium carbonate / tetrahydrofuran; water / 2 h / 20 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / ethanol / 1 h / 760.05 Torr

3: lithium borohydride / tetrahydrofuran / 2.5 h / 20 °C

4: caesium carbonate; XPhos / water; 1,4-dioxane / 4 h / 70 °C / Inert atmosphere

With lithium borohydride; palladium 10% on activated carbon; 1,1'-bis(di-tert-butylphosphino)ferrocene-dichloropalladium(II); hydrogen; potassium carbonate; caesium carbonate; XPhos; In tetrahydrofuran; 1,4-dioxane; ethanol; water;