Thieno[2,3-d]pyrimidine-3(2H)-acetic acid, 6-bromo-1,4-dihydro-α,α,5-trimethyl-2,4-dioxo-, 1,1-dimethylethyl ester

Base Information

Chemical Name:Thieno[2,3-d]pyrimidine-3(2H)-acetic acid, 6-bromo-1,4-dihydro-α,α,5-trimethyl-2,4-dioxo-, 1,1-dimethylethyl ester
CAS No.:1434643-33-0
Molecular Formula:C₁₅H₁₉BrN₂O₄S
Molecular Weight:403.297
Hs Code.:

Synonyms:tert-butyl 2-(6-bromo-5-methyl-2,4-dioxo-1,4-dihydrothieno[2,3-d]pyrimidine-3(2H)-yl)-2-methylpropanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Thieno[2,3-d]pyrimidine-3(2H)-acetic acid, 6-bromo-1,4-dihydro-α,α,5-trimethyl-2,4-dioxo-, 1,1-dimethylethyl ester

Chemical Property:

PKA:10.86±0.20(Predicted)
Density:1.471±0.06 g/cm3(Predicted)

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of Thieno[2,3-d]pyrimidine-3(2H)-acetic acid, 6-bromo-1,4-dihydro-α,α,5-trimethyl-2,4-dioxo-, 1,1-dimethylethyl ester

There total 10 articles about Thieno[2,3-d]pyrimidine-3(2H)-acetic acid, 6-bromo-1,4-dihydro-α,α,5-trimethyl-2,4-dioxo-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.2%

: 1434643-28-3
tert-butyl 2-methyl-2-(5-methyl-2,4-dioxo-1,4-dihydrothieno[2,3-d]pyrimidine-3(2H)-yl)propanoate

: 1434643-33-0
tert-butyl 2-(6-bromo-5-methyl-2,4-dioxo-1,4-dihydrothieno[2,3-d]pyrimidine-3(2H)-yl)-2-methylpropanoate

Guidance literature:: With bromine; sodium acetate; acetic acid; at 20 ℃; for 1h;

Reference yield: 75.68%

: ethyl 5-bromo-4-methyl-2-[3-(1-methyl-1-tert-butoxycarbonylethyl)ureido]-3-thenoate

: 1434643-33-0
tert-butyl 2-(6-bromo-5-methyl-2,4-dioxo-1,4-dihydrothieno[2,3-d]pyrimidine-3(2H)-yl)-2-methylpropanoate

Guidance literature:: With potassium tert-butylate; In 1,4-dioxane; at 40 - 50 ℃; for 1h; Temperature; Inert atmosphere; Large scale;

Reference yield:

: 4815-30-9
diethyl 5-amino-3-methyl-2,4-thiophenedicarboxylate

: 1434643-33-0
tert-butyl 2-(6-bromo-5-methyl-2,4-dioxo-1,4-dihydrothieno[2,3-d]pyrimidine-3(2H)-yl)-2-methylpropanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / 1,4-dioxane / 0.25 h / 10 °C

1.2: 10 - 100 °C

2.1: sodium hydroxide; water / methanol / 4 h / 50 °C

3.1: potassium carbonate; silver(I) acetate; 1-methyl-pyrrolidin-2-one / 2 h / 110 °C

4.1: bromine; CH₃COONa / acetic acid / 1 h / 20 °C

With 1-methyl-pyrrolidin-2-one; CH₃COONa; water; bromine; silver(I) acetate; sodium hydride; potassium carbonate; sodium hydroxide; In 1,4-dioxane; methanol; acetic acid;