diethyl 5-{[(2-tert-butoxy-1,1-dimethyl-2-oxoethyl)carbamoyl] amino}-3-methylthiophene-2,4-dicarboxylate

Base Information

• Chemical Name: diethyl 5-{[(2-tert-butoxy-1,1-dimethyl-2-oxoethyl)carbamoyl] amino}-3-methylthiophene-2,4-dicarboxylate
• CAS No.: 1434643-13-6
• Molecular Formula: C₂₀H₃₀N₂O₇S
• Molecular Weight: 442.533
• Mol file: 1434643-13-6.mol

Synonyms:diethyl 5-{[(2-tert-butoxy-1,1-dimethyl-2-oxoethyl)carbamoyl] amino}-3-methylthiophene-2,4-dicarboxylate

Chemical Property of diethyl 5-{[(2-tert-butoxy-1,1-dimethyl-2-oxoethyl)carbamoyl] amino}-3-methylthiophene-2,4-dicarboxylate

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diethyl 5-{[(2-tert-butoxy-1,1-dimethyl-2-oxoethyl)carbamoyl] amino}-3-methylthiophene-2,4-dicarboxylate

There total 8 articles about diethyl 5-{[(2-tert-butoxy-1,1-dimethyl-2-oxoethyl)carbamoyl] amino}-3-methylthiophene-2,4-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

phosgene (75-44-5) + diethyl 5-amino-3-methyl-2,4-thiophenedicarboxylate (4815-30-9) + 2-amino-isobutyric acid tert-butyl ester hydrochloride (84758-81-6) → diethyl 5-{[(2-tert-butoxy-1,1-dimethyl-2-oxoethyl)carbamoyl] amino}-3-methylthiophene-2,4-dicarboxylate (1434643-13-6)

Guidance literature:

phosgene; diethyl 5-amino-3-methyl-2,4-thiophenedicarboxylate; In toluene; acetonitrile; at 0 ℃; for 0.166667h;

With triethylamine; In toluene; acetonitrile; at 0 ℃; for 1.58333h;

2-amino-isobutyric acid tert-butyl ester hydrochloride; In toluene; acetonitrile; for 0.5h; Solvent;

Reference yield: 53.0%

diethyl 5-amino-3-methyl-2,4-thiophenedicarboxylate (4815-30-9) + bis(trichloromethyl) carbonate (32315-10-9) + H-Aib-OtBu (4512-32-7) → diethyl 5-{[(2-tert-butoxy-1,1-dimethyl-2-oxoethyl)carbamoyl] amino}-3-methylthiophene-2,4-dicarboxylate (1434643-13-6)

Guidance literature:

diethyl 5-amino-3-methyl-2,4-thiophenedicarboxylate; bis(trichloromethyl) carbonate; With triethylamine; In dichloromethane; at 0 ℃; for 2h; Inert atmosphere;

H-Aib-OtBu; In dichloromethane; at 20 ℃;

Reference yield: 31.0%

diethyl 5-amino-3-methyl-2,4-thiophenedicarboxylate (4815-30-9) + H-Aib-OtBu (4512-32-7) → diethyl 5-{[(2-tert-butoxy-1,1-dimethyl-2-oxoethyl)carbamoyl] amino}-3-methylthiophene-2,4-dicarboxylate (1434643-13-6)

Guidance literature:

diethyl 5-amino-3-methyl-2,4-thiophenedicarboxylate; With bis(trichloromethyl) carbonate; triethylamine; In dichloromethane; at 0 ℃; for 5h; Inert atmosphere;

H-Aib-OtBu; In dichloromethane; at 0 - 20 ℃;

upstream raw materials:

ethyl acetoacetate

ethyl 2-cyanoacetate

diethyl 5-amino-3-methyl-2,4-thiophenedicarboxylate

H-Aib-OtBu