(4-{Benzyloxycarbonyl-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-amino}-butyl)-carbamic acid benzyl ester

Base Information

Chemical Name:(4-{Benzyloxycarbonyl-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-amino}-butyl)-carbamic acid benzyl ester
CAS No.:197971-54-3
Molecular Formula:C₃₉H₄₈N₂O₅Si
Molecular Weight:652.906
Hs Code.:

Synonyms:(4-{Benzyloxycarbonyl-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-amino}-butyl)-carbamic acid benzyl ester

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Chemical Property of (4-{Benzyloxycarbonyl-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-amino}-butyl)-carbamic acid benzyl ester

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Technology Process of (4-{Benzyloxycarbonyl-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-amino}-butyl)-carbamic acid benzyl ester

There total 1 articles about (4-{Benzyloxycarbonyl-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-amino}-butyl)-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: N-(4-Azido-butyl)-N-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-4-methyl-benzenesulfonamide

: 197971-54-3
(4-{Benzyloxycarbonyl-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-amino}-butyl)-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: sodium naphthalenide / 1,2-dimethoxy-ethane / 1 h / -78 °C

2: Et₃N, DMAP / CH₂Cl₂ / 24 h / Ambient temperature

With dmap; sodium naphthalenide; triethylamine; In 1,2-dimethoxyethane; dichloromethane;
DOI:10.1021/jm970414b

Reference yield: 81.0%

: 197971-54-3
(4-{Benzyloxycarbonyl-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-amino}-butyl)-carbamic acid benzyl ester

: 197971-38-3
{4-[Benzyloxycarbonyl-(3-hydroxy-propyl)-amino]-butyl}-carbamic acid benzyl ester

Guidance literature:: With tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran; for 6h; Ambient temperature;
DOI:10.1021/jm970414b

Reference yield:

: 197971-54-3
(4-{Benzyloxycarbonyl-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-amino}-butyl)-carbamic acid benzyl ester

: C₃₉H₄₃N₄O₈P

Guidance literature:: Multi-step reaction with 4 steps

1: 81 percent / TBAF, AcOH / tetrahydrofuran / 6 h / Ambient temperature

2: 85 percent / Ph₃P, DEAD / tetrahydrofuran / Ambient temperature

3: 94 percent / NH₂NH₂*H₂O / methanol / 48 h / Ambient temperature

4: 73 percent / BOP, DIEA / CH₂Cl₂ / 1.) 0 deg C, 10 min, 2.) RT, 1.5 h

With tetrabutyl ammonium fluoride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; hydrazine hydrate; acetic acid; N-ethyl-N,N-diisopropylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm970414b